Næsen kan være fokus for behandling af og profylakse mod COVID-19

Maria Rusan; Thomas Oliver Kamarauskas Ovesen; Kurt Fuursted; Therese Ovesen

Næsen kan være fokus for behandling af og profylakse mod COVID-19

Translated title of the contribution: The nose can be the focus of treatment and prophylactic approaches against COVID-19

Maria Rusan, Thomas Oliver Kamarauskas Ovesen, Kurt Fuursted, Therese Ovesen^*

^*Corresponding author for this work

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Abstract

Infection with SARS-CoV-2 frequently commences in the nasal cavity, yet knowledge about this initial virus-host interaction is sparse. In this review, we update our current understanding of SARS-CoV-2 infection via the nasal epithelium and the associated local immune response. Furthermore, we present considerations to how this interaction may influence the clinical course of COVID-19 and the systemic immune response, and lastly touch upon the potential for intranasal vaccination, intranasal antiviral therapies and immunomodulatory approaches

Translated title of the contribution	The nose can be the focus of treatment and prophylactic approaches against COVID-19
Original language	Danish
Article number	V05210442
Journal	Ugeskrift for Læger
Volume	183
Issue	2
Number of pages	9
ISSN	0041-5782
Publication status	Published - Jan 2022

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Næsen kan være fokus for behandling af og profylakse mod COVID-19Final published version, 857 KBLicence: CC BY-NC-ND

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abstract = "Infection with SARS-CoV-2 frequently commences in the nasal cavity, yet knowledge about this initial virus-host interaction is sparse. In this review, we update our current understanding of SARS-CoV-2 infection via the nasal epithelium and the associated local immune response. Furthermore, we present considerations to how this interaction may influence the clinical course of COVID-19 and the systemic immune response, and lastly touch upon the potential for intranasal vaccination, intranasal antiviral therapies and immunomodulatory approaches",

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AU - Ovesen, Therese

PY - 2022/1

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N2 - Infection with SARS-CoV-2 frequently commences in the nasal cavity, yet knowledge about this initial virus-host interaction is sparse. In this review, we update our current understanding of SARS-CoV-2 infection via the nasal epithelium and the associated local immune response. Furthermore, we present considerations to how this interaction may influence the clinical course of COVID-19 and the systemic immune response, and lastly touch upon the potential for intranasal vaccination, intranasal antiviral therapies and immunomodulatory approaches

AB - Infection with SARS-CoV-2 frequently commences in the nasal cavity, yet knowledge about this initial virus-host interaction is sparse. In this review, we update our current understanding of SARS-CoV-2 infection via the nasal epithelium and the associated local immune response. Furthermore, we present considerations to how this interaction may influence the clinical course of COVID-19 and the systemic immune response, and lastly touch upon the potential for intranasal vaccination, intranasal antiviral therapies and immunomodulatory approaches

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M3 - Tidsskriftartikel

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Næsen kan være fokus for behandling af og profylakse mod COVID-19

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