TY - JOUR
T1 - Myeloproliferative Neoplasms and Dementia Risk
T2 - A Population-Based Cohort Study
AU - Sun, Yuelian
AU - Veres, Katalin
AU - Hasselbalch, Hans Carl
AU - Frederiksen, Henrik
AU - Østgård, Lene Sofie Granfeldt
AU - Horváth-Puhó, Erzsébet
AU - Henderson, Victor W
AU - Sørensen, Henrik Toft
PY - 2025/1
Y1 - 2025/1
N2 - Objectives: To estimate dementia risk for persons diagnosed with Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs), which serve as a human chronic inflammation model. Methods: We identified 9895 individuals in Denmark newly diagnosed with MPNs from 1995 to 2017; matched them 10:1 by age and sex with a general population cohort of 95 770 individuals; and followed them until dementia identification, death, emigration, or December 31, 2018. We applied a Cox proportional-hazards regression model to estimate the cause-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for dementia. We included control diseases, like chronic lymphocytic leukemia (CLL), which is not characterized by chronic inflammation. Results: Patients with MPNs showed a 1.15-fold (95% CI: 1.04–1.27) increased incidence of dementia compared with members of the general population. Associations were stronger for men with MPNs (HR: 1.40, 95% CI: 1.19–1.63) than for women (HR: 1.02, 95% CI: 0.89–1.15). Patients with CLL showed a decreased dementia incidence (HR: 0.81, 95% CI: 0.72–0.90). The findings for CLL could be explained by depletion-of- susceptibles bias, suggesting that the findings for MPNs were underestimated by a similar bias. Conclusions: The findings support MPNs as risk factors for dementia and the role of chronic inflammation in dementia development.
AB - Objectives: To estimate dementia risk for persons diagnosed with Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs), which serve as a human chronic inflammation model. Methods: We identified 9895 individuals in Denmark newly diagnosed with MPNs from 1995 to 2017; matched them 10:1 by age and sex with a general population cohort of 95 770 individuals; and followed them until dementia identification, death, emigration, or December 31, 2018. We applied a Cox proportional-hazards regression model to estimate the cause-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for dementia. We included control diseases, like chronic lymphocytic leukemia (CLL), which is not characterized by chronic inflammation. Results: Patients with MPNs showed a 1.15-fold (95% CI: 1.04–1.27) increased incidence of dementia compared with members of the general population. Associations were stronger for men with MPNs (HR: 1.40, 95% CI: 1.19–1.63) than for women (HR: 1.02, 95% CI: 0.89–1.15). Patients with CLL showed a decreased dementia incidence (HR: 0.81, 95% CI: 0.72–0.90). The findings for CLL could be explained by depletion-of- susceptibles bias, suggesting that the findings for MPNs were underestimated by a similar bias. Conclusions: The findings support MPNs as risk factors for dementia and the role of chronic inflammation in dementia development.
KW - chronic inflammation
KW - cohort study
KW - dementia
KW - depletion-of-susceptibles bias
KW - myeloproliferative neoplasms
KW - negative control
UR - http://www.scopus.com/inward/record.url?scp=85204240260&partnerID=8YFLogxK
U2 - 10.1111/ejh.14297
DO - 10.1111/ejh.14297
M3 - Journal article
C2 - 39279726
SN - 0902-4506
VL - 114
SP - 45
EP - 56
JO - European Journal of Haematology
JF - European Journal of Haematology
IS - 1
ER -