Musical Listening in Electric Hearing –Two Novel EEG Paradigms for Studying Music Discrimination in Cochlear Implant Users

TY - CONF

T1 - Musical Listening in Electric Hearing –Two Novel EEG Paradigms for Studying Music Discrimination in Cochlear Implant Users

AU - Petersen, Bjørn

AU - Friis Andersen, Anne Sofie

AU - Dietz, Martin

AU - Højlund, Andreas

AU - Brattico, Elvira

AU - Haumann, Niels Trusbak

AU - Michel, Franck

AU - Kamaric Riis, Søren

AU - Vuust, Peter

PY - 2018/8/20

Y1 - 2018/8/20

N2 - Musical Listening in Electric Hearing – Two Novel EEG Paradigms for Studying Music Discrimination in Cochlear Implant Users Anne Sofie Friis Andersen a*, Bjørn Petersen a*, Martin Dietz b, Andreas Højlund b, Elvira Brattico a, Niels Trusbak Haumann a, Franck Michel c, Søren Kamaric Riis d, Peter Vuust a a) Center for Music in the Brain, dpt. of Clinical Medicine, Aarhus University & The Royal Academy of Music Aarhus/Aalborg. b) Center for Functionally Integrative Neuroscience. c) Clinic of Audiology, Aarhus University Hospital, d) Oticon Medical *shared first authorship Introduction Music listening with a cochlear implant (CI) is challenging due to the poor representation of fine structure information. Therefore, extensive research has been initiated in the quest for improved music perception with a CI. Typically, musical skills are measured by behavioural methods. However, to provide objective measurements and an understanding of the cortical changes which underlie the auditory progress, neuroimaging methods are in demand. EEG is a non-invasive, silent and objective method which enables recording of event-related brain potentials (ERPs) and offers the opportunity to investigate the neural basis of perception with a high temporal resolution. The current study was initiated in cooperation with the Danish CI manufacturer Oticon Medical (OM) with two goals. In the first step, the goal is to develop and validate two novel musical EEG paradigms to be used in future CI research. 1) A multifeature MMN paradigm, presenting four deviants (pitch, intensity, timbre and rhythm) at four levels of magnitude in a no-standards configuration, and 2) a naturalistic paradigm presenting three ecological musical pieces. In a parallel step, we aim to examine the effect of a novel sound compression strategy (VoiceGuard) developed by OM. Compared to the typical automatic gain control, VoiceGuard leaves room for a wider dynamic range, which could prove beneficial for the music perception of CI users. As data collection from CI users has not been concluded at the time of submission, results from normal-hearing (NH) participants are reported. Methods/Results Two groups of NH participants were included and subjected to the tests: a group of young adults (N: 17, mean age 25) and a group of older adults (N: 14, mean age 63). The MMN paradigm elicited significant MMN responses for all deviants in both groups. Furthermore, MMN amplitude strengths were in accordance with the levels of deviance. Results from a supplementary behavioural measurement confirmed the overall findings of the MMN measurements. The naturalistic paradigm elicited significant P2 responses for the musical features spectral flux, brightness, roughness and RMS. Perspectives The NH results suggest encouraging potential for using the paradigm in future CI research. As a preliminary finding, we have been able to show significant MMN responses in single subject analyses. With clinical application in mind, this is important since it suggests potential use of the MMN paradigm for objective prognostication and assessment of CI functioning in individual CI patients. The study is work in progress and so far, data from eight experienced and eight newly operated CI users have been collected. We expect preliminary results from these groups to be available for presentation at the conference.

AB - Musical Listening in Electric Hearing – Two Novel EEG Paradigms for Studying Music Discrimination in Cochlear Implant Users Anne Sofie Friis Andersen a*, Bjørn Petersen a*, Martin Dietz b, Andreas Højlund b, Elvira Brattico a, Niels Trusbak Haumann a, Franck Michel c, Søren Kamaric Riis d, Peter Vuust a a) Center for Music in the Brain, dpt. of Clinical Medicine, Aarhus University & The Royal Academy of Music Aarhus/Aalborg. b) Center for Functionally Integrative Neuroscience. c) Clinic of Audiology, Aarhus University Hospital, d) Oticon Medical *shared first authorship Introduction Music listening with a cochlear implant (CI) is challenging due to the poor representation of fine structure information. Therefore, extensive research has been initiated in the quest for improved music perception with a CI. Typically, musical skills are measured by behavioural methods. However, to provide objective measurements and an understanding of the cortical changes which underlie the auditory progress, neuroimaging methods are in demand. EEG is a non-invasive, silent and objective method which enables recording of event-related brain potentials (ERPs) and offers the opportunity to investigate the neural basis of perception with a high temporal resolution. The current study was initiated in cooperation with the Danish CI manufacturer Oticon Medical (OM) with two goals. In the first step, the goal is to develop and validate two novel musical EEG paradigms to be used in future CI research. 1) A multifeature MMN paradigm, presenting four deviants (pitch, intensity, timbre and rhythm) at four levels of magnitude in a no-standards configuration, and 2) a naturalistic paradigm presenting three ecological musical pieces. In a parallel step, we aim to examine the effect of a novel sound compression strategy (VoiceGuard) developed by OM. Compared to the typical automatic gain control, VoiceGuard leaves room for a wider dynamic range, which could prove beneficial for the music perception of CI users. As data collection from CI users has not been concluded at the time of submission, results from normal-hearing (NH) participants are reported. Methods/Results Two groups of NH participants were included and subjected to the tests: a group of young adults (N: 17, mean age 25) and a group of older adults (N: 14, mean age 63). The MMN paradigm elicited significant MMN responses for all deviants in both groups. Furthermore, MMN amplitude strengths were in accordance with the levels of deviance. Results from a supplementary behavioural measurement confirmed the overall findings of the MMN measurements. The naturalistic paradigm elicited significant P2 responses for the musical features spectral flux, brightness, roughness and RMS. Perspectives The NH results suggest encouraging potential for using the paradigm in future CI research. As a preliminary finding, we have been able to show significant MMN responses in single subject analyses. With clinical application in mind, this is important since it suggests potential use of the MMN paradigm for objective prognostication and assessment of CI functioning in individual CI patients. The study is work in progress and so far, data from eight experienced and eight newly operated CI users have been collected. We expect preliminary results from these groups to be available for presentation at the conference.

M3 - Poster

T2 - 2nd International Music and CI symposium

Y2 - 20 August 2018 through 21 August 2018

ER -