Multiple Point Stimulation MUNE in ALS

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Multiple Point Stimulation MUNE in ALS. / Oliveira Santos, Miguel; Jacobsen, Anna Bystrup; Tankisi, Hatice.

In: Journal of Clinical Neurophysiology, Vol. 36, No. 3, 05.2019, p. 220-223.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Oliveira Santos, M, Jacobsen, AB & Tankisi, H 2019, 'Multiple Point Stimulation MUNE in ALS', Journal of Clinical Neurophysiology, vol. 36, no. 3, pp. 220-223. https://doi.org/10.1097/WNP.0000000000000578

APA

Oliveira Santos, M., Jacobsen, A. B., & Tankisi, H. (2019). Multiple Point Stimulation MUNE in ALS. Journal of Clinical Neurophysiology, 36(3), 220-223. https://doi.org/10.1097/WNP.0000000000000578

CBE

Oliveira Santos M, Jacobsen AB, Tankisi H. 2019. Multiple Point Stimulation MUNE in ALS. Journal of Clinical Neurophysiology. 36(3):220-223. https://doi.org/10.1097/WNP.0000000000000578

MLA

Oliveira Santos, Miguel, Anna Bystrup Jacobsen, and Hatice Tankisi. "Multiple Point Stimulation MUNE in ALS". Journal of Clinical Neurophysiology. 2019, 36(3). 220-223. https://doi.org/10.1097/WNP.0000000000000578

Vancouver

Oliveira Santos M, Jacobsen AB, Tankisi H. Multiple Point Stimulation MUNE in ALS. Journal of Clinical Neurophysiology. 2019 May;36(3):220-223. https://doi.org/10.1097/WNP.0000000000000578

Author

Oliveira Santos, Miguel ; Jacobsen, Anna Bystrup ; Tankisi, Hatice. / Multiple Point Stimulation MUNE in ALS. In: Journal of Clinical Neurophysiology. 2019 ; Vol. 36, No. 3. pp. 220-223.

Bibtex

@article{ef6d1723219f403b887140d95fcb4e1d,
title = "Multiple Point Stimulation MUNE in ALS",
abstract = "PURPOSE: Multiple point stimulation is a well-established motor unit number estimate method that can be used in all EMG machines, but it is time-consuming. We investigated whether a faster modification of multiple point stimulation using five surface motor unit action potentials (sMUAP) had similar reproducibility, sensitivity, and specificity as 10. METHODS: Twenty-two motor neuron disease patients and 20 healthy controls were prospectively examined by two physicians twice in the thenar muscles. RESULTS: A total of 168 multiple point stimulation motor unit number estimate recordings were obtained. Mean motor unit number estimate was significantly lower in patients in contrast to the controls, whether using 5 (53 ± 55 [1-170] vs. 150 ± 64 (51-325), P < 0.001] or 10 sMUAP [52 ± 51 (1-162) vs. 151 ± 50 (75-274), P < 0.001]. No significant differences (P > 0.05) were found between mean motor unit number estimate obtained from 5 or 10 sMUAP in both patients and controls. Intra-rater coefficient of variation (CV) for patients (17% vs. 15%) and controls (16% vs. 13%) and inter-rater coefficient of variation for patients (25% vs. 24%) did not differ between five and 10 sMUAP (P > 0.05), whereas interrater coefficient of variation was higher for five sMUAP in controls (21% vs. 16%, P = 0.004). An excellent intraclass correlation coefficient (≥0.78) was found, sampling either 5 or 10 sMUAP, for both groups. Receiver operating characteristic curves collecting 5 or 10 sMUAP showed excellent accuracy in distinguishing between patients and controls. CONCLUSIONS: The faster modification of Multiple point stimulation by sampling five sMUAP had similar reproducibility, sensitivity, and specificity as 10 and may be suggested in future research and clinical practice.",
author = "{Oliveira Santos}, Miguel and Jacobsen, {Anna Bystrup} and Hatice Tankisi",
year = "2019",
month = may,
doi = "10.1097/WNP.0000000000000578",
language = "English",
volume = "36",
pages = "220--223",
journal = "Journal of Clinical Neurophysiology",
issn = "0736-0258",
publisher = "LIPPINCOTT WILLIAMS & WILKINS",
number = "3",

}

RIS

TY - JOUR

T1 - Multiple Point Stimulation MUNE in ALS

AU - Oliveira Santos, Miguel

AU - Jacobsen, Anna Bystrup

AU - Tankisi, Hatice

PY - 2019/5

Y1 - 2019/5

N2 - PURPOSE: Multiple point stimulation is a well-established motor unit number estimate method that can be used in all EMG machines, but it is time-consuming. We investigated whether a faster modification of multiple point stimulation using five surface motor unit action potentials (sMUAP) had similar reproducibility, sensitivity, and specificity as 10. METHODS: Twenty-two motor neuron disease patients and 20 healthy controls were prospectively examined by two physicians twice in the thenar muscles. RESULTS: A total of 168 multiple point stimulation motor unit number estimate recordings were obtained. Mean motor unit number estimate was significantly lower in patients in contrast to the controls, whether using 5 (53 ± 55 [1-170] vs. 150 ± 64 (51-325), P < 0.001] or 10 sMUAP [52 ± 51 (1-162) vs. 151 ± 50 (75-274), P < 0.001]. No significant differences (P > 0.05) were found between mean motor unit number estimate obtained from 5 or 10 sMUAP in both patients and controls. Intra-rater coefficient of variation (CV) for patients (17% vs. 15%) and controls (16% vs. 13%) and inter-rater coefficient of variation for patients (25% vs. 24%) did not differ between five and 10 sMUAP (P > 0.05), whereas interrater coefficient of variation was higher for five sMUAP in controls (21% vs. 16%, P = 0.004). An excellent intraclass correlation coefficient (≥0.78) was found, sampling either 5 or 10 sMUAP, for both groups. Receiver operating characteristic curves collecting 5 or 10 sMUAP showed excellent accuracy in distinguishing between patients and controls. CONCLUSIONS: The faster modification of Multiple point stimulation by sampling five sMUAP had similar reproducibility, sensitivity, and specificity as 10 and may be suggested in future research and clinical practice.

AB - PURPOSE: Multiple point stimulation is a well-established motor unit number estimate method that can be used in all EMG machines, but it is time-consuming. We investigated whether a faster modification of multiple point stimulation using five surface motor unit action potentials (sMUAP) had similar reproducibility, sensitivity, and specificity as 10. METHODS: Twenty-two motor neuron disease patients and 20 healthy controls were prospectively examined by two physicians twice in the thenar muscles. RESULTS: A total of 168 multiple point stimulation motor unit number estimate recordings were obtained. Mean motor unit number estimate was significantly lower in patients in contrast to the controls, whether using 5 (53 ± 55 [1-170] vs. 150 ± 64 (51-325), P < 0.001] or 10 sMUAP [52 ± 51 (1-162) vs. 151 ± 50 (75-274), P < 0.001]. No significant differences (P > 0.05) were found between mean motor unit number estimate obtained from 5 or 10 sMUAP in both patients and controls. Intra-rater coefficient of variation (CV) for patients (17% vs. 15%) and controls (16% vs. 13%) and inter-rater coefficient of variation for patients (25% vs. 24%) did not differ between five and 10 sMUAP (P > 0.05), whereas interrater coefficient of variation was higher for five sMUAP in controls (21% vs. 16%, P = 0.004). An excellent intraclass correlation coefficient (≥0.78) was found, sampling either 5 or 10 sMUAP, for both groups. Receiver operating characteristic curves collecting 5 or 10 sMUAP showed excellent accuracy in distinguishing between patients and controls. CONCLUSIONS: The faster modification of Multiple point stimulation by sampling five sMUAP had similar reproducibility, sensitivity, and specificity as 10 and may be suggested in future research and clinical practice.

UR - http://www.scopus.com/inward/record.url?scp=85068197487&partnerID=8YFLogxK

U2 - 10.1097/WNP.0000000000000578

DO - 10.1097/WNP.0000000000000578

M3 - Journal article

C2 - 30882531

AN - SCOPUS:85068197487

VL - 36

SP - 220

EP - 223

JO - Journal of Clinical Neurophysiology

JF - Journal of Clinical Neurophysiology

SN - 0736-0258

IS - 3

ER -