Multipathway Antibacterial Mechanism of a Nanoparticle-Supported Artemisinin Promoted by Nitrogen Plasma Treatment

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DOI

  • Haiying Cui, Jiangsu University
  • ,
  • Xiaochen Chen
  • Mei Bai, Jiangsu University
  • ,
  • Dong Han, National Center for Nanoscience and Technology Beijing
  • ,
  • Lin Lin, School of Food and Biological Engineering, Jiangsu University
  • ,
  • Mingdong Dong

Artemisinin has excellent antimalarial, antiparasitic, and antibacterial activities; however, the poor water solubility of artemisinin crystal limits their application in antibiosis. Herein, artemisinin crystal was first composited with silica nanoparticles (SNPs) to form an artemisinin@silica nanoparticle (A@SNP). After treating with nitrogen plasma, the aqueous solubility of plasma-treated A@SNP (A@SNP-p) approaches 42.26%, which is possibly attributed to the exposure of hydrophilic groups such as -OH groups on the SNPs during the plasma process. Compared with the pristine A@SNP, the antibacterial activity of A@SNP-p against both Gram-positive and Gram-negative strains is further enhanced, and its bactericidal rate against both strains exceeded 6 log CFU/mL (>99.9999%), which is contributed by the increased water solubility of the A@SNP-p. A possible multipathway antibacterial mechanism of A@SNP was proposed and preliminarily proved by the changes of intracellular materials of bacteria and the inhibition of bacterial metabolism processes, including the HMP pathway in Gram-negative strain and EMP pathway in Gram-positive strain, after treating with A@SNP-p. These findings from the present work will provide a new view for fabricating artemisinin-based materials as antibiotics.

Original languageEnglish
JournalACS Applied Materials and Interfaces
Volume11
Issue50
Pages (from-to)47299-47310
Number of pages12
ISSN1944-8244
DOIs
Publication statusPublished - 18 Dec 2019

    Research areas

  • antibacterial, artemisinin, multipathway mechanism, nitrogen plasma, silica nanoparticles

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