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Multiparametric Model for Penumbral Flow Prediction in Acute Stroke

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  • Michelle Livne, Charite Univ Med Berlin, Free University of Berlin, Humboldt University of Berlin, Charite Medical University of Berlin, Ctr Stroke Res Berlin CSB
  • ,
  • Tabea Kossen, Charite Univ Med Berlin, Free University of Berlin, Humboldt University of Berlin, Charite Medical University of Berlin, Ctr Stroke Res Berlin CSB
  • ,
  • Vince I. Madai, Charite Univ Med Berlin, Humboldt University of Berlin, Free University of Berlin, Charite Medical University of Berlin, Dept Neurosurg
  • ,
  • Olivier Zaro-Weber, Max Planck Inst Neurol Res, Max Planck Society
  • ,
  • Walter Moeller-Hartmann, Ludmillenstift Meppen, Dept Radiol
  • ,
  • Kim Mouridsen
  • Wolf-Dieter Heiss, Max Planck Inst Neurol Res, Max Planck Society
  • ,
  • Jan Sobesky, Charite Univ Med Berlin, Free University of Berlin, Humboldt University of Berlin, Charite Medical University of Berlin, Ctr Stroke Res Berlin CSB

Background and Purpose-Identification of salvageable penumbra tissue by dynamic susceptibility contrast magnetic resonance imaging is a valuable tool for acute stroke patient stratification for treatment. However, prior studies have not attempted to combine the different perfusion maps into a predictive model. In this study, we established a multiparametric perfusion imaging model and cross-validated it using positron emission tomography perfusion for detection of penumbral flow.

Methods-In a retrospective analysis of 17 subacute stroke patients with consecutive magnetic resonance imaging and H2O15 positron emission tomography scans, perfusion maps of cerebral blood flow, cerebral blood volume, mean transit time, time-to-maximum, and time-to-peak were constructed and combined using a generalized linear model (GLM). Both the GLM maps and the single perfusion maps alone were cross-validated with positron emission tomography-cerebral blood flow scans to predict penumbral flow on a voxel-wise level. Performance was tested by receiver-operating characteristics curve analysis, that is, the area under the curve, and the models' fits were compared using the likelihood ratio test.

Results-The GLM demonstrated significantly improved model fit compared with each of the single perfusion maps (P

Conclusions-Our results support a dynamic susceptibility contrast magnetic resonance imaging-based GLM as an improved model for penumbral flow prediction in stroke patients. With given perfusion maps, this model is a straightforward and observer-independent alternative for therapy stratification.

Original languageEnglish
JournalStroke
Volume48
Issue7
Pages (from-to)1849-1854
Number of pages6
ISSN0039-2499
DOIs
Publication statusPublished - Jul 2017

    Research areas

  • acute stroke, cerebrovascular circulation, magnetic resonance imaging, perfusion imaging, positron emission tomography, ACUTE ISCHEMIC-STROKE, POSITRON-EMISSION-TOMOGRAPHY, ARTERIAL INPUT FUNCTION, ENDOVASCULAR THERAPY, PERFUSION MRI, VALIDATION, PET, NEUROPROTECTION, THRESHOLD, SELECTION

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