Multilayer DNA Origami Packed on Hexagonal and Hybrid Lattices

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  • Yonggang Ke, Harvard Medical School, United States
  • Niels Vinther Voigt, Denmark
  • William M. Shih, Harvard Medical School, United States
  • Kurt Vesterager Gothelf
“Scaffolded DNA origami” has been proven to be a powerful and efficient approach to construct two-dimensional or three-dimensional objects with great complexity. Multilayer DNA origami has been demonstrated with helices packing along either honeycomb-lattice geometry or square-lattice geometry. Here we report successful folding of multilayer DNA origami with helices arranged on a close-packed hexagonal lattice. This arrangement yields a higher density of helical packing and therefore higher resolution of spatial addressing than has been shown previously. We also demonstrate hybrid multilayer DNA origami with honeycomb-lattice, square-lattice, and hexagonal-lattice packing of helices all in one design. The availability of hexagonal close-packing of helices extends our ability to build complex structures using DNA nanotechnology.
Original languageEnglish
JournalJournal of the American Chemical Society
Volume134
Issue3
Pages (from-to)1770-1774
Number of pages5
ISSN0002-7863
DOIs
Publication statusPublished - 2012

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