Multifunctional Bi@PPy-PEG Core-Shell Nanohybrids for Dual-Modal Imaging and Photothermal Therapy

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

  • Sisi Yang, Harbin Inst Technol, Sch Chem Engn & Technol, State Key Lab Urban Water Resource & Environm
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  • Zhenglin Li, Harbin Inst Technol, Sch Chem Engn & Technol, State Key Lab Urban Water Resource & Environm
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  • Yuanlin Wang, Harbin Inst Technol, Sch Chem Engn & Technol, State Key Lab Urban Water Resource & Environm
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  • Xuelei Fang, Harbin Inst Technol, Sch Chem Engn & Technol, State Key Lab Urban Water Resource & Environm
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  • Zhaohua Miao, Harbin Inst Technol, Sch Mat Sci & Engn
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  • Ying Hu, Harbin Inst Technol, Harbin Institute of Technology, Sch Life Sci & Technol
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  • Zhuo Li, Harbin Inst Technol, Sch Chem Engn & Technol, State Key Lab Urban Water Resource & Environm
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  • Ye Sun, Harbin Inst Technol, Condensed Matter Sci & Technol Inst
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  • Flemming Besenhacher
  • Miao Yu, Harbin Inst Technol, Sch Chem Engn & Technol, State Key Lab Urban Water Resource & Environm

High-performance theranostic nanoagents, which integrate multi-modal imaging and photothermal therapy for clinical anticancer treatment, are highly desired. Herein, we report the synthesis and bioapplication of a multifunctional theranostic nanoagent based on polyethylene glycol (PEG)-modified polypyrrole (PPy)-coated bismuth (Bi) nanohybrids (referred to as Bi@PPy-PEG NHs) for X-ray computed tomography/photoacoustic (CT/PA) dual-modal imaging and photothermal therapy (PTT). The obtained Bi@PPy-PEG NHs have a distinct core-shell structure with the metallic Bi nanoparticle as the inner core and the PPy-PEG layer as the shell. The Bi@PPy-PEG NHs show excellent physiological stability and compatibility, without noticeable cytotoxicity. Importantly, the NHs exhibit strong NIR absorbance and remarkable photothermal conversion capability and conversion stability, with the photothermal conversion efficiency as high as similar to 46.3%. Thanks to the strong PTT effect, highly effective photothermal ablation on cancer cells has been achieved both in vitro and in vivo. Furthermore, a high-contrast in vitro and in vivo CT/PA dual-modal imaging has been realized, showing great potential to provide comprehensive diagnosis information for antitumor treatment. In particular, the CT enhancement efficiency of the NHs is of similar to 14.4 HU mM(-1), which is similar to 3.7-fold that of clinically used iohexol. Therefore, our work highlights the potential of using such core-shell Bi@PPy-PEG NHs as a versatile theranostic nanoplatform for cancer imaging and therapy.

Original languageEnglish
JournalA C S Applied Materials and Interfaces
Volume10
Issue2
Pages (from-to)1605-1615
Number of pages11
ISSN1944-8244
DOIs
Publication statusPublished - 17 Jan 2018

    Research areas

  • bismuth nanoparticles, photothermal therapy, computed tomography imaging, photoacoustic imaging, core-shell structure, RAY COMPUTED-TOMOGRAPHY, IN-VIVO, DRUG-DELIVERY, GOLD NANOPARTICLES, COMPOSITE NANOPARTICLES, BISMUTH NANOPARTICLES, THERANOSTIC AGENT, CONTRAST AGENTS, CANCER, TUMOR

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