Multi-Shell Hollow Nanogels with Responsive Shell Permeability

Andreas J. Schmid, Janine Dubbert, Andrey A. Rudov, Jan Skov Pedersen, Peter Lindner, Matthias Karg, Igor I. Potemkin*, Walter Richtering

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

We report on hollow shell-shell nanogels with two polymer shells that have different volume phase transition temperatures. By means of small angle neutron scattering (SANS) employing contrast variation and molecular dynamics (MD) simulations we show that hollow shell-shell nanocontainers are ideal systems for controlled drug delivery: The temperature responsive swelling of the inner shell controls the uptake and release, while the thermoresponsive swelling of the outer shell controls the size of the void and the colloidal stability. At temperatures between 32 °C < T < 42 °C, the hollow nanocontainers provide a significant void, which is even larger than the initial core size of the template, and they possess a high colloidal stability due to the steric stabilization of the swollen outer shell. Computer simulations showed, that temperature induced switching of the permeability of the inner shell allows for the encapsulation in and release of molecules from the cavity.

Original languageEnglish
Article number22736
JournalScientific Reports
Volume6
Number of pages13
ISSN2045-2322
DOIs
Publication statusPublished - 2016

Keywords

  • MESOPOROUS SILICA NANOCONTAINERS
  • CATIONIC NANOHYDROGEL PARTICLES
  • DRUG-DELIVERY
  • N-ISOPROPYLACRYLAMIDE
  • CONTROLLED-RELEASE
  • MICROGEL CAPSULES
  • SIRNA DELIVERY
  • PH
  • ENCAPSULATION
  • CARRIERS

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