Mucopenetrating Micelles with a PEG Corona

Essi Marika Taipaleenmäki, Sidsel Mouritzen, Philipp Schattling, Yan Zhang, Brigitte Maria Stadler

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27 Citations (Scopus)

Abstract

Crossing the intestinal mucus layer is a long-standing challenge for orally delivered nanoparticles carrying therapeutic cargo. We report the assembly of mucopenetrating cargo-loaded micelles using block copolymers consisting of either linear poly(ethylene glycol) (PEG) or bottle-brush poly(oligo(ethylene glycol)methacrylate) (PEG b) as the hydrophilic block and poly(caprolactone) (PCL) or poly(cholesteryl methacrylate) (PCMA) as the hydrophobic extension. The micelles were shown to preserve their stability and retain ∼50% of their cargo in simulated gastric fluid. The ability of micelles to diffuse through reconstituted porcine mucus was assessed in a microfluidic set-up. Finally, the delivery of Nile Red as a hydrophobic model cargo across a mucus layer produced by epithelial cells was demonstrated. These engineered mucopenetrating micelles have potential to be developed into efficient absorption enhancers, contributing a nanotechnology solution to oral drug delivery.

Original languageEnglish
JournalNanoscale
Volume9
Issue46
Pages (from-to)18438-18448
Number of pages10
ISSN2040-3364
DOIs
Publication statusPublished - 14 Dec 2017

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