Morphological and functional imaging studies on the diagnosis and progression of Parkinson's disease

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

This paper reviews the relative abilities of magnetic resonance imaging (MRI), positron emission tomography (PET), single photon emission tomography (SPECT), and proton magnetic resonance spectroscopy (MRS) to detect Parkinson's disease and monitor its progression. Currently, the main role of MRI lies in its ability to discriminate atypical syndromes from Parkinson's disease; however, new volumetric approaches may soon allow progression of nigral degeneration to be followed. Proton MRS can also detect reduced levels of putamen N-acetyl aspartate (NAA) in many patients with atypical parkinsonian syndromes. PET and SPECT are both sensitive means of detecting the presence of impaired dopamine terminal function in the striatum and following its progression. PET currently has the greater spatial resolution and provides the added advantages that it also allows extra-striatal dopaminergic function to be monitored.

Original languageEnglish
JournalJournal of Neurology, Supplement
Volume247
Issue2
Pages (from-to)11-18
Number of pages8
ISSN0939-1517
Publication statusPublished - 1 Apr 2000
Externally publishedYes

    Research areas

  • Diagnosis, MRI, MRS, Parkinson's disease, PET, SPECT

See relations at Aarhus University Citationformats

ID: 132379902