Mood Disorders and Risk of Herpes Zoster in 2 Population-Based Case-Control Studies in Denmark and the United Kingdom

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  • Sigrun A J Schmidt
  • Sinéad M Langan, London School of Hygiene and Tropical Medicine, University of London, UK
  • ,
  • Henrik S Pedersen
  • Henrik Carl Schønheyder
  • Sara L Thomas, London School of Hygiene and Tropical Medicine, University of London, UK
  • ,
  • Liam Smeeth, London School of Hygiene and Tropical Medicine, University of London, UK
  • ,
  • Kathryn E Mansfield, London School of Hygiene and Tropical Medicine, University of London, UK
  • ,
  • Henrik T Sørensen
  • Harriet J Forbes, London School of Hygiene and Tropical Medicine, University of London, UK
  • ,
  • Mogens Vestergaard

We examined the association between mood disorders and risk of herpes zoster in two case-control studies using data from nationwide Danish registries and practices in the UK Clinical Practice Research Datalink. We included incident zoster cases diagnosed in general practice (using systemic antivirals as a proxy in Denmark) or hospital during 1997-2013 in Denmark (n = 190,671) and during 2000-2013 in the United Kingdom (n = 177,361). We risk-set sampled 4 matched population controls per case. Conditional logistic regression analyses adjusting for zoster risk factors showed that the odds ratios for previous mood disorder among cases versus controls were 1.15 (99% confidence interval (CI): 1.12, 1.19; prevalence 7.1% vs. 6.0%) in Denmark and 1.12 (99% CI: 1.11, 1.14; prevalence 31.6% vs. 29.2%) in the United Kingdom. In Denmark, odds ratios were higher for anxiety (1.23; 99% CI: 1.17, 1.30) and severe stress and adjustment disorder (1.24; 99% CI: 1.18, 1.30) than for depression (1.11; 99% CI: 1.07, 1.14). In the United Kingdom, odds ratios for these conditions were similar: 1.12 (99% CI: 1.10, 1.13), 1.12 (99% CI: 1.10, 1.14), and 1.14 (99% CI: 1.10, 1.19) for depression, anxiety, and severe stress and adjustment disorder, respectively. In conclusion, mood disorders were associated with an increased risk of zoster.

Original languageEnglish
JournalAmerican Journal of Epidemiology
Volume187
Issue5
Pages (from-to)1019-1028
Number of pages10
ISSN0002-9262
DOIs
Publication statusPublished - May 2018

    Research areas

  • adjustment disorders, anxiety, depression, herpes zoster, stress disorders, DEPRESSION, PSYCHOLOGICAL STRESS, VIRUS, DIAGNOSES, VACCINE, ADULTS, DISEASES, REGISTRATION, EPIDEMIOLOGY, SIMPLEX

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