Monitoring patterned enzymatic polymerization on DNA origami at single-molecule level

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DNA origami has been used to orchestrate reactions with nano-precision using a variety of biomolecules. Here, the dynamics of albumin-assisted, localized single-molecule DNA polymerization by terminal deoxynucleotidyl transferase on a 2D DNA origami are monitored using AFM in liquid. Direct visualization of the surface activity revealed the mechanics of growth.

Original languageEnglish
JournalNanoscale
Volume7
Issue25
Pages (from-to)10970-10973
Number of pages4
ISSN2040-3364
DOIs
Publication statusPublished - 7 Jul 2015

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