Molecular recognition and homochirality preservation of guanine tetrads in the presence of melamine

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  • Yanghan Chen, Harbin Institute of Technology
  • ,
  • Chong Chen, Harbin Institute of Technology
  • ,
  • Pengcheng Ding, Harbin Institute of Technology
  • ,
  • Guoqiang Shi, Harbin Institute of Technology
  • ,
  • Ye Sun, Harbin Institute of Technology
  • ,
  • Lev N. Kantorovich, King’s College London
  • ,
  • Flemming Besenbacher
  • Miao Yu, Harbin Institute of Technology

Molecular recognition between nucleobases plays a crucial role in all kinds of biological processes. However, real-space investigation of the recognition capability of nucleobases in the presence of interfering compounds remains unexplored. Herein, based on the combination of scanning tunneling microscopy imaging and density functional theory modeling, we report the impact of the presence of melamine (M) on the formation and chirality of guanine (G)-tetrads on Au(111). Although M can interact with G by double hydrogen bonding, the Hoogsteen base pairing of G is not compromised, forming identical individual G-tetrads as would have happened without the presence of M. G-tetrads coexist with M on the surface not only in separate domains, but also within the mixture network of G-tetrads and M-dimers. Although the adsorption orientation of G-tetrads in the mixture network diversifies into two distinct angles, all G-tetrads in the network keep the same chirality, emphasizing the high preference of homochirality in such biochemical systems.

Original languageEnglish
JournalNano Research
Pages (from-to)2427-2430
Number of pages4
Publication statusPublished - Sep 2020

    Research areas

  • molecular recognition, guanine-tetrad, base pairing, homochirality, biochemical synthesis, G-QUADRUPLEXES, COADSORPTION, QUARTETS, ORIGIN

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