Molecular definitions of autophagy and related processes

Lorenzo Galluzzi; Eric H Baehrecke; Andrea Ballabio; Patricia Boya; José Manuel Bravo-San Pedro; Francesco Cecconi; Augustine M Choi; Charleen T Chu; Patrice Codogno; Maria Isabel Colombo; Ana Maria Cuervo; Jayanta Debnath; Vojo Deretic; Ivan Dikic; Eeva-Liisa Eskelinen; Gian Maria Fimia; Simone Fulda; David A Gewirtz; Douglas R Green; Malene Hansen; J Wade Harper; Marja Jäättelä; Terje Johansen; Gabor Juhasz; Alec C Kimmelman; Claudine Kraft; Nicholas T Ktistakis; Sharad Kumar; Beth Levine; Carlos Lopez-Otin; Frank Madeo; Sascha Martens; Jennifer Martinez; Alicia Melendez; Noboru Mizushima; Christian Münz; Leon O Murphy; Josef M Penninger; Mauro Piacentini; Fulvio Reggiori; David C Rubinsztein; Kevin M Ryan; Laura Santambrogio; Luca Scorrano; Anna Katharina Simon; Hans-Uwe Simon; Anne Simonsen; Nektarios Tavernarakis; Sharon A Tooze; Tamotsu Yoshimori; Junying Yuan; Zhenyu Yue; Qing Zhong; Guido Kroemer

doi:10.15252/embj.201796697

Molecular definitions of autophagy and related processes

Lorenzo Galluzzi, Eric H Baehrecke, Andrea Ballabio, Patricia Boya, José Manuel Bravo-San Pedro, Francesco Cecconi, Augustine M Choi, Charleen T Chu, Patrice Codogno, Maria Isabel Colombo, Ana Maria Cuervo, Jayanta Debnath, Vojo Deretic, Ivan Dikic, Eeva-Liisa Eskelinen, Gian Maria Fimia, Simone Fulda, David A Gewirtz, Douglas R Green, Malene HansenJ Wade Harper, Marja Jäättelä, Terje Johansen, Gabor Juhasz, Alec C Kimmelman, Claudine Kraft, Nicholas T Ktistakis, Sharad Kumar, Beth Levine, Carlos Lopez-Otin, Frank Madeo, Sascha Martens, Jennifer Martinez, Alicia Melendez, Noboru Mizushima, Christian Münz, Leon O Murphy, Josef M Penninger, Mauro Piacentini, Fulvio Reggiori, David C Rubinsztein, Kevin M Ryan, Laura Santambrogio, Luca Scorrano, Anna Katharina Simon, Hans-Uwe Simon, Anne Simonsen, Nektarios Tavernarakis, Sharon A Tooze, Tamotsu Yoshimori, Junying Yuan, Zhenyu Yue, Qing Zhong, Guido Kroemer

Department of Clinical Medicine - Research Unit for Molecular Medicine

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

1250 Citations (Scopus)

Abstract

Over the past two decades, the molecular machinery that underlies autophagic responses has been characterized with ever increasing precision in multiple model organisms. Moreover, it has become clear that autophagy and autophagy-related processes have profound implications for human pathophysiology. However, considerable confusion persists about the use of appropriate terms to indicate specific types of autophagy and some components of the autophagy machinery, which may have detrimental effects on the expansion of the field. Driven by the overt recognition of such a potential obstacle, a panel of leading experts in the field attempts here to define several autophagy-related terms based on specific biochemical features. The ultimate objective of this collaborative exchange is to formulate recommendations that facilitate the dissemination of knowledge within and outside the field of autophagy research.

Original language	English
Journal	The EMBO Journal
Volume	36
Issue	13
Pages (from-to)	1811-1836
Number of pages	26
ISSN	0261-4189
DOIs	https://doi.org/10.15252/embj.201796697
Publication status	Published - 3 Jul 2017

Keywords

Animals
Autophagy
Caenorhabditis elegans/physiology
Drosophila melanogaster/physiology
Gene Regulatory Networks
Mice
Saccharomyces cerevisiae/physiology
Terminology as Topic

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Galluzzi, L., Baehrecke, E. H., Ballabio, A., Boya, P., Bravo-San Pedro, J. M., Cecconi, F., Choi, A. M., Chu, C. T., Codogno, P., Colombo, M. I., Cuervo, A. M., Debnath, J., Deretic, V., Dikic, I., Eskelinen, E.-L., Fimia, G. M., Fulda, S., Gewirtz, D. A., Green, D. R., ... Kroemer, G. (2017). Molecular definitions of autophagy and related processes. The EMBO Journal, 36(13), 1811-1836. https://doi.org/10.15252/embj.201796697

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abstract = "Over the past two decades, the molecular machinery that underlies autophagic responses has been characterized with ever increasing precision in multiple model organisms. Moreover, it has become clear that autophagy and autophagy-related processes have profound implications for human pathophysiology. However, considerable confusion persists about the use of appropriate terms to indicate specific types of autophagy and some components of the autophagy machinery, which may have detrimental effects on the expansion of the field. Driven by the overt recognition of such a potential obstacle, a panel of leading experts in the field attempts here to define several autophagy-related terms based on specific biochemical features. The ultimate objective of this collaborative exchange is to formulate recommendations that facilitate the dissemination of knowledge within and outside the field of autophagy research.",

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author = "Lorenzo Galluzzi and Baehrecke, {Eric H} and Andrea Ballabio and Patricia Boya and {Bravo-San Pedro}, {Jos{\'e} Manuel} and Francesco Cecconi and Choi, {Augustine M} and Chu, {Charleen T} and Patrice Codogno and Colombo, {Maria Isabel} and Cuervo, {Ana Maria} and Jayanta Debnath and Vojo Deretic and Ivan Dikic and Eeva-Liisa Eskelinen and Fimia, {Gian Maria} and Simone Fulda and Gewirtz, {David A} and Green, {Douglas R} and Malene Hansen and Harper, {J Wade} and Marja J{\"a}{\"a}ttel{\"a} and Terje Johansen and Gabor Juhasz and Kimmelman, {Alec C} and Claudine Kraft and Ktistakis, {Nicholas T} and Sharad Kumar and Beth Levine and Carlos Lopez-Otin and Frank Madeo and Sascha Martens and Jennifer Martinez and Alicia Melendez and Noboru Mizushima and Christian M{\"u}nz and Murphy, {Leon O} and Penninger, {Josef M} and Mauro Piacentini and Fulvio Reggiori and Rubinsztein, {David C} and Ryan, {Kevin M} and Laura Santambrogio and Luca Scorrano and Simon, {Anna Katharina} and Hans-Uwe Simon and Anne Simonsen and Nektarios Tavernarakis and Tooze, {Sharon A} and Tamotsu Yoshimori and Junying Yuan and Zhenyu Yue and Qing Zhong and Guido Kroemer",

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Galluzzi, L, Baehrecke, EH, Ballabio, A, Boya, P, Bravo-San Pedro, JM, Cecconi, F, Choi, AM, Chu, CT, Codogno, P, Colombo, MI, Cuervo, AM, Debnath, J, Deretic, V, Dikic, I, Eskelinen, E-L, Fimia, GM, Fulda, S, Gewirtz, DA, Green, DR, Hansen, M, Harper, JW, Jäättelä, M, Johansen, T, Juhasz, G, Kimmelman, AC, Kraft, C, Ktistakis, NT, Kumar, S, Levine, B, Lopez-Otin, C, Madeo, F, Martens, S, Martinez, J, Melendez, A, Mizushima, N, Münz, C, Murphy, LO, Penninger, JM, Piacentini, M, Reggiori, F, Rubinsztein, DC, Ryan, KM, Santambrogio, L, Scorrano, L, Simon, AK, Simon, H-U, Simonsen, A, Tavernarakis, N, Tooze, SA, Yoshimori, T, Yuan, J, Yue, Z, Zhong, Q & Kroemer, G 2017, 'Molecular definitions of autophagy and related processes', The EMBO Journal, vol. 36, no. 13, pp. 1811-1836. https://doi.org/10.15252/embj.201796697

TY - JOUR

T1 - Molecular definitions of autophagy and related processes

AU - Galluzzi, Lorenzo

AU - Baehrecke, Eric H

AU - Ballabio, Andrea

AU - Boya, Patricia

AU - Bravo-San Pedro, José Manuel

AU - Cecconi, Francesco

AU - Choi, Augustine M

AU - Chu, Charleen T

AU - Codogno, Patrice

AU - Colombo, Maria Isabel

AU - Cuervo, Ana Maria

AU - Debnath, Jayanta

AU - Deretic, Vojo

AU - Dikic, Ivan

AU - Eskelinen, Eeva-Liisa

AU - Fimia, Gian Maria

AU - Fulda, Simone

AU - Gewirtz, David A

AU - Green, Douglas R

AU - Hansen, Malene

AU - Harper, J Wade

AU - Jäättelä, Marja

AU - Johansen, Terje

AU - Juhasz, Gabor

AU - Kimmelman, Alec C

AU - Kraft, Claudine

AU - Ktistakis, Nicholas T

AU - Kumar, Sharad

AU - Levine, Beth

AU - Lopez-Otin, Carlos

AU - Madeo, Frank

AU - Martens, Sascha

AU - Martinez, Jennifer

AU - Melendez, Alicia

AU - Mizushima, Noboru

AU - Münz, Christian

AU - Murphy, Leon O

AU - Penninger, Josef M

AU - Piacentini, Mauro

AU - Reggiori, Fulvio

AU - Rubinsztein, David C

AU - Ryan, Kevin M

AU - Santambrogio, Laura

AU - Scorrano, Luca

AU - Simon, Anna Katharina

AU - Simon, Hans-Uwe

AU - Simonsen, Anne

AU - Tavernarakis, Nektarios

AU - Tooze, Sharon A

AU - Yoshimori, Tamotsu

AU - Yuan, Junying

AU - Yue, Zhenyu

AU - Zhong, Qing

AU - Kroemer, Guido

PY - 2017/7/3

Y1 - 2017/7/3

N2 - Over the past two decades, the molecular machinery that underlies autophagic responses has been characterized with ever increasing precision in multiple model organisms. Moreover, it has become clear that autophagy and autophagy-related processes have profound implications for human pathophysiology. However, considerable confusion persists about the use of appropriate terms to indicate specific types of autophagy and some components of the autophagy machinery, which may have detrimental effects on the expansion of the field. Driven by the overt recognition of such a potential obstacle, a panel of leading experts in the field attempts here to define several autophagy-related terms based on specific biochemical features. The ultimate objective of this collaborative exchange is to formulate recommendations that facilitate the dissemination of knowledge within and outside the field of autophagy research.

AB - Over the past two decades, the molecular machinery that underlies autophagic responses has been characterized with ever increasing precision in multiple model organisms. Moreover, it has become clear that autophagy and autophagy-related processes have profound implications for human pathophysiology. However, considerable confusion persists about the use of appropriate terms to indicate specific types of autophagy and some components of the autophagy machinery, which may have detrimental effects on the expansion of the field. Driven by the overt recognition of such a potential obstacle, a panel of leading experts in the field attempts here to define several autophagy-related terms based on specific biochemical features. The ultimate objective of this collaborative exchange is to formulate recommendations that facilitate the dissemination of knowledge within and outside the field of autophagy research.

KW - Animals

KW - Autophagy

KW - Caenorhabditis elegans/physiology

KW - Drosophila melanogaster/physiology

KW - Gene Regulatory Networks

KW - Mice

KW - Saccharomyces cerevisiae/physiology

KW - Terminology as Topic

U2 - 10.15252/embj.201796697

DO - 10.15252/embj.201796697

M3 - Review

C2 - 28596378

SN - 0261-4189

VL - 36

SP - 1811

EP - 1836

JO - The EMBO Journal

JF - The EMBO Journal

IS - 13

ER -

Molecular definitions of autophagy and related processes

Abstract

Keywords

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