Molecular characterization and temporal expression profiling of presenilins in the developing porcine brain

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  • The Department of Oto-Rhino-Laryngology
  • Department of Genetics and Biotechnology
  • Molekylær Genetik og Systembiologi
  • Institute of Clinical Medicine
  • Patologisk Institut, Aalborg Sygehus Nord
  • Department of Human Genetics
  • Faculty of Science
The transmembrane presenilin (PSEN) proteins, PSEN1 and PSEN2, have been proposed to be the catalytic components of the gamma-secretase protein complex, which is an intramembranous multimeric protease involved in development, cell regulatory processes, and neurodegeneration in Alzheimer's disease. Here we describe the sequencing, chromosomal mapping, and polymorphism analysis of PSEN1 and PSEN2 in the domestic pig (Sus scrofa domesticus).
Original languageEnglish
JournalB M C Neuroscience
Volume8
Issue72
Pages (from-to)1-11
Number of pages11
ISSN1471-2202
DOIs
Publication statusPublished - 1 Jan 2007

    Research areas

  • Amino Acid Sequence, Animals, Brain, Gene Expression Profiling, Gene Expression Regulation, Developmental, Humans, Membrane Proteins, Molecular Sequence Data, Presenilin-1, Presenilin-2, Sequence Homology, Amino Acid, Sus scrofa, Swine, Time Factors

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