Molecular characterization and temporal expression profiling of presenilins in the developing porcine brain

Lone B Madsen, Bo Thomsen, Knud Erik Larsen, Christian Bendixen, Ida E Holm, Merete Fredholm, Arne L Jørgensen, Anders L Nielsen, Anders Lade Nielsen

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    Abstract

    The transmembrane presenilin (PSEN) proteins, PSEN1 and PSEN2, have been proposed to be the catalytic components of the gamma-secretase protein complex, which is an intramembranous multimeric protease involved in development, cell regulatory processes, and neurodegeneration in Alzheimer's disease. Here we describe the sequencing, chromosomal mapping, and polymorphism analysis of PSEN1 and PSEN2 in the domestic pig (Sus scrofa domesticus).
    Original languageEnglish
    JournalB M C Neuroscience
    Volume8
    Issue72
    Pages (from-to)1-11
    Number of pages11
    ISSN1471-2202
    DOIs
    Publication statusPublished - 1 Jan 2007

    Keywords

    • Amino Acid Sequence
    • Animals
    • Brain
    • Gene Expression Profiling
    • Gene Expression Regulation, Developmental
    • Humans
    • Membrane Proteins
    • Molecular Sequence Data
    • Presenilin-1
    • Presenilin-2
    • Sequence Homology, Amino Acid
    • Sus scrofa
    • Swine
    • Time Factors

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