Modified Rotational Thromboelastometry Protocol Using Tissue Plasminogen Activator for Detection of Hypofibrinolysis and Hyperfibrinolysis

Julie Brogaard Larsen*, Christine Lodberg Hvas, Anne Mette Hvas

*Corresponding author for this work

Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

3 Citations (Scopus)

Abstract

Viscoelastic testing includes thromboelastography (TEG®) and thromboelastometry (ROTEM®) and is widely used in bleeding patients to detect hypocoagulability and guide transfusion therapy. However, the ability of standard viscoelastic tests to assess fibrinolytic capacity is limited. We here describe a modified ROTEM® protocol with addition of tissue plasminogen activator that can be used to identify hypofibrinolysis or hyperfibrinolysis.

Original languageEnglish
Title of host publicationHemostasis and Thrombosis : Methods and Protocols
EditorsEmmanuel J. Favaloro, Robert C. Gosselin
Number of pages11
Volume2663
Place of publicationNew York
PublisherHumana Press
Publication date2023
Pages763-773
Chapter51
ISBN (Print) 978-1-0716-3174-4
ISBN (Electronic)978-1-0716-3175-1
DOIs
Publication statusPublished - 2023
SeriesMethods in Molecular Biology
Volume2663
ISSN1064-3745

Keywords

  • Fibrinolysis
  • Rotational thromboelastometry
  • Tissue plasminogen activator
  • Viscoelastic tests

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