Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

Bjarni J Vilhjálmsson; Jian Yang; Hilary K Finucane; Alexander Gusev; Sara Lindström; Stephan Ripke; Giulio Genovese; Po-Ru Loh; Gaurav Bhatia; Ron Do; Tristan Hayeck; Hong-Hee Won; Sekar Kathiresan; Michele Pato; Carlos Pato; Rulla Tamimi; Eli Stahl; Noah Zaitlen; Bogdan Pasaniuc; Gillian Belbin; Eimear E Kenny; Mikkel H Schierup; Philip De Jager; Nikolaos A Patsopoulos; Steve McCarroll; Mark Daly; Shaun Purcell; Daniel Chasman; Benjamin Neale; Michael Goddard; Peter M Visscher; Peter Kraft; Nick Patterson; Alkes L Price; Schizophrenia Working Group of the Psychiatric Genomics Consortium (Jakob Grove, member); Jakob Grove; Schizophrenia Working Group of the Psychiatric Genomics Consortium (Anders Børglum, member of -); Anders Børglum

doi:10.1016/j.ajhg.2015.09.001

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

Bjarni J Vilhjálmsson, Jian Yang, Hilary K Finucane, Alexander Gusev, Sara Lindström, Stephan Ripke, Giulio Genovese, Po-Ru Loh, Gaurav Bhatia, Ron Do, Tristan Hayeck, Hong-Hee Won, Sekar Kathiresan, Michele Pato, Carlos Pato, Rulla Tamimi, Eli Stahl, Noah Zaitlen, Bogdan Pasaniuc, Gillian BelbinEimear E Kenny, Mikkel H Schierup, Philip De Jager, Nikolaos A Patsopoulos, Steve McCarroll, Mark Daly, Shaun Purcell, Daniel Chasman, Benjamin Neale, Michael Goddard, Peter M Visscher, Peter Kraft, Nick Patterson, Alkes L Price, Schizophrenia Working Group of the Psychiatric Genomics Consortium (Jakob Grove, member), Jakob Grove (Editor), Schizophrenia Working Group of the Psychiatric Genomics Consortium (Anders Børglum, member of -), Anders Børglum (Member of author collaboration)

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Original language	English
Journal	American Journal of Human Genetics
Volume	97
Issue	4
Pages (from-to)	576-92
Number of pages	17
ISSN	0002-9297
DOIs	https://doi.org/10.1016/j.ajhg.2015.09.001
Publication status	Published - 1 Oct 2015

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10.1016/j.ajhg.2015.09.001

iPSYCH: The Lundbeck Foundation Initiative for Integrative Psychiatric Research
Bang Rasmussen, A. (Participant)
01/01/2015 → …
Project: Research

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Vilhjálmsson, B. J., Yang, J., Finucane, H. K., Gusev, A., Lindström, S., Ripke, S., Genovese, G., Loh, P.-R., Bhatia, G., Do, R., Hayeck, T., Won, H.-H., Kathiresan, S., Pato, M., Pato, C., Tamimi, R., Stahl, E., Zaitlen, N., Pasaniuc, B., ... Børglum, A. (2015). Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores. American Journal of Human Genetics, 97(4), 576-92. https://doi.org/10.1016/j.ajhg.2015.09.001

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title = "Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores",

author = "Vilhj{\'a}lmsson, {Bjarni J} and Jian Yang and Finucane, {Hilary K} and Alexander Gusev and Sara Lindstr{\"o}m and Stephan Ripke and Giulio Genovese and Po-Ru Loh and Gaurav Bhatia and Ron Do and Tristan Hayeck and Hong-Hee Won and Sekar Kathiresan and Michele Pato and Carlos Pato and Rulla Tamimi and Eli Stahl and Noah Zaitlen and Bogdan Pasaniuc and Gillian Belbin and Kenny, {Eimear E} and Schierup, {Mikkel H} and {De Jager}, Philip and Patsopoulos, {Nikolaos A} and Steve McCarroll and Mark Daly and Shaun Purcell and Daniel Chasman and Benjamin Neale and Michael Goddard and Visscher, {Peter M} and Peter Kraft and Nick Patterson and Price, {Alkes L} and {Schizophrenia Working Group of the Psychiatric Genomics Consortium (Jakob Grove, member)} and Jakob Grove and {Schizophrenia Working Group of the Psychiatric Genomics Consortium (Anders B{\o}rglum, member of -)} and Anders B{\o}rglum",

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doi = "10.1016/j.ajhg.2015.09.001",

language = "English",

volume = "97",

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journal = "American Journal of Human Genetics",

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Vilhjálmsson, BJ, Yang, J, Finucane, HK, Gusev, A, Lindström, S, Ripke, S, Genovese, G, Loh, P-R, Bhatia, G, Do, R, Hayeck, T, Won, H-H, Kathiresan, S, Pato, M, Pato, C, Tamimi, R, Stahl, E, Zaitlen, N, Pasaniuc, B, Belbin, G, Kenny, EE, Schierup, MH, De Jager, P, Patsopoulos, NA, McCarroll, S, Daly, M, Purcell, S, Chasman, D, Neale, B, Goddard, M, Visscher, PM, Kraft, P, Patterson, N, Price, AL, Schizophrenia Working Group of the Psychiatric Genomics Consortium (Jakob Grove, member), Grove, J (ed.), Schizophrenia Working Group of the Psychiatric Genomics Consortium (Anders Børglum, member of -) & Børglum, A 2015, 'Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores', American Journal of Human Genetics, vol. 97, no. 4, pp. 576-92. https://doi.org/10.1016/j.ajhg.2015.09.001

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores. / Vilhjálmsson, Bjarni J; Yang, Jian; Finucane, Hilary K et al.
In: American Journal of Human Genetics, Vol. 97, No. 4, 01.10.2015, p. 576-92.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

AU - Vilhjálmsson, Bjarni J

AU - Yang, Jian

AU - Finucane, Hilary K

AU - Gusev, Alexander

AU - Lindström, Sara

AU - Ripke, Stephan

AU - Genovese, Giulio

AU - Loh, Po-Ru

AU - Bhatia, Gaurav

AU - Do, Ron

AU - Hayeck, Tristan

AU - Won, Hong-Hee

AU - Kathiresan, Sekar

AU - Pato, Michele

AU - Pato, Carlos

AU - Tamimi, Rulla

AU - Stahl, Eli

AU - Zaitlen, Noah

AU - Pasaniuc, Bogdan

AU - Belbin, Gillian

AU - Kenny, Eimear E

AU - Schierup, Mikkel H

AU - De Jager, Philip

AU - Patsopoulos, Nikolaos A

AU - McCarroll, Steve

AU - Daly, Mark

AU - Purcell, Shaun

AU - Chasman, Daniel

AU - Neale, Benjamin

AU - Goddard, Michael

AU - Visscher, Peter M

AU - Kraft, Peter

AU - Patterson, Nick

AU - Price, Alkes L

AU - Schizophrenia Working Group of the Psychiatric Genomics Consortium (Jakob Grove, member)

AU - Schizophrenia Working Group of the Psychiatric Genomics Consortium (Anders Børglum, member of -)

AU - Børglum, Anders

A2 - Grove, Jakob

PY - 2015/10/1

Y1 - 2015/10/1

U2 - 10.1016/j.ajhg.2015.09.001

DO - 10.1016/j.ajhg.2015.09.001

M3 - Journal article

C2 - 26430803

SN - 0002-9297

VL - 97

SP - 576

EP - 592

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 4

ER -

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

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iPSYCH: The Lundbeck Foundation Initiative for Integrative Psychiatric Research

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