Mitochondrial helicases and mitochondrial genome maintenance

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  • Maria Diget Aamann, Denmark
  • Nadja C de Souza-Pinto
  • ,
  • Tomasz Kulikowicz
  • ,
  • Tinna V Stevnsner
  • Vilhelm A Bohr, Denmark
  • Department of Molecular Biology
  • Danish Centre for Molecular Gerontology
Helicases are essential enzymes that utilize the energy of nucleotide hydrolysis to drive unwinding of nucleic acid duplexes. Helicases play roles in all aspects of DNA metabolism including DNA repair, DNA replication and transcription. The subcellular locations and functions of several helicases have been studied in detail; however, the roles of specific helicases in mitochondrial biology remain poorly characterized. This review presents important recent advances in identifying and characterizing mitochondrial helicases, some of which also operate in the nucleus.
Original languageEnglish
JournalMechanisms of Ageing and Development
Volume131
Issue7-8
Pages (from-to)503-10
Number of pages8
ISSN0047-6374
DOIs
Publication statusPublished - 2010

    Research areas

  • Age Factors, Aging, Animals, DNA Helicases, DNA, Mitochondrial, Gene Expression Regulation, Humans, Mitochondria

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