Mitochondrial helicases and mitochondrial genome maintenance

Maria Diget Aamann, Nadja C de Souza-Pinto, Tomasz Kulikowicz, Tinna V Stevnsner, Vilhelm A Bohr

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

    Abstract

    Helicases are essential enzymes that utilize the energy of nucleotide hydrolysis to drive unwinding of nucleic acid duplexes. Helicases play roles in all aspects of DNA metabolism including DNA repair, DNA replication and transcription. The subcellular locations and functions of several helicases have been studied in detail; however, the roles of specific helicases in mitochondrial biology remain poorly characterized. This review presents important recent advances in identifying and characterizing mitochondrial helicases, some of which also operate in the nucleus.
    Original languageEnglish
    JournalMechanisms of Ageing and Development
    Volume131
    Issue7-8
    Pages (from-to)503-10
    Number of pages8
    ISSN0047-6374
    DOIs
    Publication statusPublished - 2010

    Keywords

    • Age Factors
    • Aging
    • Animals
    • DNA Helicases
    • DNA, Mitochondrial
    • Gene Expression Regulation
    • Humans
    • Mitochondria

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