miRNA Signature in Early-stage Mycosis Fungoides

Sissel T Sørensen, Thomas Litman, Maria Gluud, Pamela Celis, Sara Torres-Rusillo, Andreas Willerslev-Olsen, Niels Ødum, Lars Iversen, Lise M Lindahl

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Abstract

Altered miRNA expressions are assigned pathogenic properties in several cancers including mycosis fungoides and could play a role in the early onset of the disease. The aim of this study was to examine disease-specific miRNA expression in early-stage mycosis fungoides patch and plaque lesions. A quantitative real-time PCR platform of 384 human miRNAs was used to study miRNA expression in 154 diagnostic mycosis fungoides biopsies. A total of 110 miRNAs were significantly differentially expressed (>2-fold, p < 0.05) between plaque lesions and healthy controls, and 90 miRNAs (>2-fold, p < 0.05) differed between patch lesions and healthy controls. Moreover, 13 miRNAs differed in expression between patch and plaque lesions. Early-stage mycosis fungoides exhibited miRNA features that overlapped with those of psoriasis. However, 39 miRNAs, including miR-142-3p, miR-150 and miR-146b, were specific to mycosis fungoides. In conclusion, early-stage mycosis fungoides expresses a distinct miRNA profile, indicating that miRNAs could play a role in the early development of mycosis fungoides.

Original languageEnglish
Article numberadv00785
JournalActa Dermato-Venereologica
Volume102
ISSN0001-5555
DOIs
Publication statusPublished - Oct 2022

Keywords

  • cancer
  • cutaneous T-cell lymphoma
  • microRNA
  • mycosis fungoides

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