Mining of lethal recessive genetic variation in Danish cattle

Research output: Book/anthology/dissertation/reportPh.D. thesisResearch

  • Ashutosh Das, Denmark
The widespread use of artificial insemination in cattle breeding Worldwide leads to reduced effective population sizes and increased inbreeding levels. Increased inbreeding result in increased probalility of expression of recessive defective alleles, which probably is reflected in a decline in fertility. The primary objective of this PhD projekt was to identify recessive lethal gentic variants in the main Danish dairy cattle breed. Holstein-Friesian utilzing next generation sequencing (NGS) data. This study shows a potential for the use of the NGS-based reverse genetic approach in identifying lethal or semi-lethal recessive gentic variation
Original languageEnglish
Number of pages187
ISBN (Print)978-87-93398-07-8
Publication statusPublished - 10 Dec 2015

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