Minimum information guidelines for experiments structurally characterizing intrinsically disordered protein regions

Bálint Mészáros; András Hatos; Nicolas Palopoli; Federica Quaglia; Edoardo Salladini; Kim Van Roey; Haribabu Arthanari; Zsuzsanna Dosztányi; Isabella C. Felli; Patrick D. Fischer; Jeffrey C. Hoch; Cy M. Jeffries; Sonia Longhi; Emiliano Maiani; Sandra Orchard; Rita Pancsa; Elena Papaleo; Roberta Pierattelli; Damiano Piovesan; Iva Pritisanac; Luiggi Tenorio; Thibault Viennet; Peter Tompa; Wim Vranken; Silvio C.E. Tosatto; Norman E. Davey

doi:10.1038/s41592-023-01915-x

Minimum information guidelines for experiments structurally characterizing intrinsically disordered protein regions

Bálint Mészáros, András Hatos, Nicolas Palopoli, Federica Quaglia, Edoardo Salladini, Kim Van Roey, Haribabu Arthanari, Zsuzsanna Dosztányi, Isabella C. Felli, Patrick D. Fischer, Jeffrey C. Hoch, Cy M. Jeffries, Sonia Longhi, Emiliano Maiani, Sandra Orchard, Rita Pancsa, Elena Papaleo, Roberta Pierattelli, Damiano Piovesan, Iva PritisanacLuiggi Tenorio, Thibault Viennet, Peter Tompa, Wim Vranken, Silvio C.E. Tosatto, Norman E. Davey^*

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

7 Citations (Scopus)

Abstract

An unambiguous description of an experiment, and the subsequent biological observation, is vital for accurate data interpretation. Minimum information guidelines define the fundamental complement of data that can support an unambiguous conclusion based on experimental observations. We present the Minimum Information About Disorder Experiments (MIADE) guidelines to define the parameters required for the wider scientific community to understand the findings of an experiment studying the structural properties of intrinsically disordered regions (IDRs). MIADE guidelines provide recommendations for data producers to describe the results of their experiments at source, for curators to annotate experimental data to community resources and for database developers maintaining community resources to disseminate the data. The MIADE guidelines will improve the interpretability of experimental results for data consumers, facilitate direct data submission, simplify data curation, improve data exchange among repositories and standardize the dissemination of the key metadata on an IDR experiment by IDR data sources.

Original language	English
Journal	Nature Methods
Volume	20
Pages (from-to)	1291-1303
Number of pages	13
ISSN	1548-7091
DOIs	https://doi.org/10.1038/s41592-023-01915-x
Publication status	Published - Sept 2023
Externally published	Yes

Keywords

Intrinsically Disordered Proteins/chemistry
Protein Conformation

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Mészáros, B., Hatos, A., Palopoli, N., Quaglia, F., Salladini, E., Van Roey, K., Arthanari, H., Dosztányi, Z., Felli, I. C., Fischer, P. D., Hoch, J. C., Jeffries, C. M., Longhi, S., Maiani, E., Orchard, S., Pancsa, R., Papaleo, E., Pierattelli, R., Piovesan, D., ... Davey, N. E. (2023). Minimum information guidelines for experiments structurally characterizing intrinsically disordered protein regions. Nature Methods, 20, 1291-1303. https://doi.org/10.1038/s41592-023-01915-x

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title = "Minimum information guidelines for experiments structurally characterizing intrinsically disordered protein regions",

abstract = "An unambiguous description of an experiment, and the subsequent biological observation, is vital for accurate data interpretation. Minimum information guidelines define the fundamental complement of data that can support an unambiguous conclusion based on experimental observations. We present the Minimum Information About Disorder Experiments (MIADE) guidelines to define the parameters required for the wider scientific community to understand the findings of an experiment studying the structural properties of intrinsically disordered regions (IDRs). MIADE guidelines provide recommendations for data producers to describe the results of their experiments at source, for curators to annotate experimental data to community resources and for database developers maintaining community resources to disseminate the data. The MIADE guidelines will improve the interpretability of experimental results for data consumers, facilitate direct data submission, simplify data curation, improve data exchange among repositories and standardize the dissemination of the key metadata on an IDR experiment by IDR data sources.",

keywords = "Intrinsically Disordered Proteins/chemistry, Protein Conformation",

author = "B{\'a}lint M{\'e}sz{\'a}ros and Andr{\'a}s Hatos and Nicolas Palopoli and Federica Quaglia and Edoardo Salladini and {Van Roey}, Kim and Haribabu Arthanari and Zsuzsanna Doszt{\'a}nyi and Felli, {Isabella C.} and Fischer, {Patrick D.} and Hoch, {Jeffrey C.} and Jeffries, {Cy M.} and Sonia Longhi and Emiliano Maiani and Sandra Orchard and Rita Pancsa and Elena Papaleo and Roberta Pierattelli and Damiano Piovesan and Iva Pritisanac and Luiggi Tenorio and Thibault Viennet and Peter Tompa and Wim Vranken and Tosatto, {Silvio C.E.} and Davey, {Norman E.}",

note = "Publisher Copyright: {\textcopyright} 2023, Springer Nature America, Inc.",

year = "2023",

month = sep,

doi = "10.1038/s41592-023-01915-x",

language = "English",

volume = "20",

pages = "1291--1303",

journal = "Nature Methods",

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Mészáros, B, Hatos, A, Palopoli, N, Quaglia, F, Salladini, E, Van Roey, K, Arthanari, H, Dosztányi, Z, Felli, IC, Fischer, PD, Hoch, JC, Jeffries, CM, Longhi, S, Maiani, E, Orchard, S, Pancsa, R, Papaleo, E, Pierattelli, R, Piovesan, D, Pritisanac, I, Tenorio, L, Viennet, T, Tompa, P, Vranken, W, Tosatto, SCE & Davey, NE 2023, 'Minimum information guidelines for experiments structurally characterizing intrinsically disordered protein regions', Nature Methods, vol. 20, pp. 1291-1303. https://doi.org/10.1038/s41592-023-01915-x

Minimum information guidelines for experiments structurally characterizing intrinsically disordered protein regions. / Mészáros, Bálint; Hatos, András; Palopoli, Nicolas et al.
In: Nature Methods, Vol. 20, 09.2023, p. 1291-1303.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Minimum information guidelines for experiments structurally characterizing intrinsically disordered protein regions

AU - Mészáros, Bálint

AU - Hatos, András

AU - Palopoli, Nicolas

AU - Quaglia, Federica

AU - Salladini, Edoardo

AU - Van Roey, Kim

AU - Arthanari, Haribabu

AU - Dosztányi, Zsuzsanna

AU - Felli, Isabella C.

AU - Fischer, Patrick D.

AU - Hoch, Jeffrey C.

AU - Jeffries, Cy M.

AU - Longhi, Sonia

AU - Maiani, Emiliano

AU - Orchard, Sandra

AU - Pancsa, Rita

AU - Papaleo, Elena

AU - Pierattelli, Roberta

AU - Piovesan, Damiano

AU - Pritisanac, Iva

AU - Tenorio, Luiggi

AU - Viennet, Thibault

AU - Tompa, Peter

AU - Vranken, Wim

AU - Tosatto, Silvio C.E.

AU - Davey, Norman E.

PY - 2023/9

Y1 - 2023/9

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AB - An unambiguous description of an experiment, and the subsequent biological observation, is vital for accurate data interpretation. Minimum information guidelines define the fundamental complement of data that can support an unambiguous conclusion based on experimental observations. We present the Minimum Information About Disorder Experiments (MIADE) guidelines to define the parameters required for the wider scientific community to understand the findings of an experiment studying the structural properties of intrinsically disordered regions (IDRs). MIADE guidelines provide recommendations for data producers to describe the results of their experiments at source, for curators to annotate experimental data to community resources and for database developers maintaining community resources to disseminate the data. The MIADE guidelines will improve the interpretability of experimental results for data consumers, facilitate direct data submission, simplify data curation, improve data exchange among repositories and standardize the dissemination of the key metadata on an IDR experiment by IDR data sources.

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KW - Protein Conformation

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U2 - 10.1038/s41592-023-01915-x

DO - 10.1038/s41592-023-01915-x

M3 - Journal article

C2 - 37400558

AN - SCOPUS:85164196588

SN - 1548-7091

VL - 20

SP - 1291

EP - 1303

JO - Nature Methods

JF - Nature Methods

ER -

Minimum information guidelines for experiments structurally characterizing intrinsically disordered protein regions

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Keywords

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