Mind the gap:: molecular architecture of the axon initial segment – from fold prediction to a mechanistic model of function?

Esben Meldgaard Høgh Quistgaard; Josephine Dannersø Nissen; Sean Hansen; Poul Nissen

doi:10.1016/j.jmb.2021.167176

Mind the gap: molecular architecture of the axon initial segment – from fold prediction to a mechanistic model of function?

Esben Meldgaard Høgh Quistgaard, Josephine Dannersø Nissen, Sean Hansen, Poul Nissen^*

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

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Abstract

The axon initial segment (AIS) is a distinct neuronal domain, which is responsible for initiating action potentials, and therefore of key importance to neuronal signaling. To determine how it functions, it is necessary to establish which proteins reside there, how they are organized, and what the dynamic features are. Great strides have been made in recent years, and it is now clear that several AIS cytoskeletal and membrane proteins interact to form a higher-order periodic structure. Here we briefly describe AIS function, protein composition and molecular architecture, and discuss perspectives for future structural characterization, and if structure predictions will be able to model complex higher-order assemblies.

Original language	English
Article number	167176
Journal	Journal of Molecular Biology
Volume	433
Issue	20
Number of pages	8
ISSN	0022-2836
DOIs	https://doi.org/10.1016/j.jmb.2021.167176
Publication status	Published - 1 Oct 2021

Keywords

action potentials
ankyrin-spectrin
axon initial segment (AIS)
membrane ultrastructure
voltage-gated ion channels

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1-s2.0-S0022283621004095-mainFinal published version, 1.05 MBLicence: CC BY

Cite this

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title = "Mind the gap:: molecular architecture of the axon initial segment – from fold prediction to a mechanistic model of function?",

abstract = "The axon initial segment (AIS) is a distinct neuronal domain, which is responsible for initiating action potentials, and therefore of key importance to neuronal signaling. To determine how it functions, it is necessary to establish which proteins reside there, how they are organized, and what the dynamic features are. Great strides have been made in recent years, and it is now clear that several AIS cytoskeletal and membrane proteins interact to form a higher-order periodic structure. Here we briefly describe AIS function, protein composition and molecular architecture, and discuss perspectives for future structural characterization, and if structure predictions will be able to model complex higher-order assemblies.",

keywords = "action potentials, ankyrin-spectrin, axon initial segment (AIS), membrane ultrastructure, voltage-gated ion channels",

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year = "2021",

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Mind the gap: molecular architecture of the axon initial segment – from fold prediction to a mechanistic model of function? / Quistgaard, Esben Meldgaard Høgh; Nissen, Josephine Dannersø ; Hansen, Sean et al.
In: Journal of Molecular Biology, Vol. 433, No. 20, 167176, 01.10.2021.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

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AU - Hansen, Sean

AU - Nissen, Poul

PY - 2021/10/1

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N2 - The axon initial segment (AIS) is a distinct neuronal domain, which is responsible for initiating action potentials, and therefore of key importance to neuronal signaling. To determine how it functions, it is necessary to establish which proteins reside there, how they are organized, and what the dynamic features are. Great strides have been made in recent years, and it is now clear that several AIS cytoskeletal and membrane proteins interact to form a higher-order periodic structure. Here we briefly describe AIS function, protein composition and molecular architecture, and discuss perspectives for future structural characterization, and if structure predictions will be able to model complex higher-order assemblies.

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KW - action potentials

KW - ankyrin-spectrin

KW - axon initial segment (AIS)

KW - membrane ultrastructure

KW - voltage-gated ion channels

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Mind the gap: molecular architecture of the axon initial segment – from fold prediction to a mechanistic model of function?

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Keywords

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