TY - JOUR
T1 - Mimer
T2 - an automated spreadsheet-based crystallization screening system
AU - Brodersen, Ditlev Egeskov
AU - Andersen, Gregers Rom
AU - Andersen, Christian Brix Folsted
PY - 2013/7/1
Y1 - 2013/7/1
N2 - In this paper, a simple low-cost alternative to large commercial systems for preparing macromolecular crystallization conditions is described. Using an intuitive spreadsheet-based approach, the system allows the rapid calculation of relevant pipetting volumes given known stock-solution concentrations and incorporates the automatic design of custom crystallization screens via the incomplete-factorial and grid-screen approaches. Automated dispensing of the resulting crystallization screens is achieved using a generic and relatively inexpensive liquid handler.
AB - In this paper, a simple low-cost alternative to large commercial systems for preparing macromolecular crystallization conditions is described. Using an intuitive spreadsheet-based approach, the system allows the rapid calculation of relevant pipetting volumes given known stock-solution concentrations and incorporates the automatic design of custom crystallization screens via the incomplete-factorial and grid-screen approaches. Automated dispensing of the resulting crystallization screens is achieved using a generic and relatively inexpensive liquid handler.
U2 - 10.1107/S1744309113014425
DO - 10.1107/S1744309113014425
M3 - Journal article
C2 - 23832216
SN - 2053-230X
VL - 69
SP - 815
EP - 820
JO - Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online
JF - Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online
IS - Pt 7
ER -