Migratory pattern of zoonotic Toxocara cati and T. canis in experimentally infected pigs

Casper Sahl Poulsen, Ayako Yoshida, Tinna Thordardottir Wellbrant, Pall Skuli Leifsson, Per Skallerup, Stig Milan Thamsborg, Peter Nejsum*

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

Background: Over a billion people are infected with Toxocara canis or T. cati, the roundworms of dogs and cats. Historically, T. canis has been considered the main species responsible for human toxocarosis, but as serodiagnosis cannot discriminate between the two species, this remains unresolved. We used pigs as a relevant large animal model for human infection to assess the migratory pattern of T. cati and T. canis. Methods: Pigs were inoculated with T. cati or T. canis eggs or PBS (negative controls) and necropsied 14 or 31 days later. Different organs and tissues were examined for parasites and pathological changes. Results: Overall, the two parasite species had a similar migration pattern reaching multiple organs and tissues, including the mesenteric lymph nodes, liver, lungs, and diaphragm. We recovered larvae of both species in the brain, suggesting that T. cati also can cause neurological toxocarosis in humans. Both species induced systemic eosinophilia and histopathological changes in the lungs, livers, and mesenteric lymph nodes. Conclusion: This study emphasises the importance of T. cati as a zoonotic agent and the need to develop diagnostic methods that can differentiate between sources of infection in humans.

Original languageEnglish
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Volume43
Issue3
Pages (from-to)587-596
Number of pages10
ISSN0934-9723
DOIs
Publication statusPublished - Mar 2024

Keywords

  • Histopathology
  • Migration pattern
  • Pathology
  • Toxocara canis
  • Toxocara cati
  • Zoonosis

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