Microsomal drug-metabolizing enzymes in the olive baboon (papio anabis).

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearch

  • Herman Autrup
  • Brenda J. Thurlow, Department of Pathology, Medical School, University of Nairobi, Nairobi, Chester Beatty Institute, Institute of Cancer Research, Royal Cancer Hospital, London, Kenya
  • Johnston Wakhisi, Department of Pathology, Medical School, University of Nairobi, Nairobi, Kenya
  • Gerald P. Warwick, Department of Pathology, Medical School, University of Nairobi, Nairobi, Chester Beatty Institute, Institute of Cancer Research, Royal Cancer Hospital, London, Kenya
  • Institute of Environmental and Occupational Medicine
1.1. The activity of microsomal drug-metabolizing enzymes—azo reductase, nitroreductase, p-hydroxylation, N-demethylation, O-demethylation, NADPH cytochrome c reductase and cytochrome P P-450—in the olive baboon are lower than in other animal species, e.g. mouse, rat, guinea-pig.
2. 2. The level is comparable with the level in man for N-demethylation, azo reductase, O-demethylation and NADPH cytochrome c reductase.
3. 3. The ratio of the activity of the p-hydroxylation as compared with cytochrome P-450 is very similar in baboon and man.
4. 4. Arylsulfatase is localized in the lysosomal fraction and beta-glucuronidase is present more in the lysosomal than in the microsomal fraction.
Original languageEnglish
JournalComparative Biochemistry and Physiology - Part B: Biochemistry & Molecular Biology
Volume50
Issue3
Pages (from-to)385-390
Number of pages6
ISSN1096-4959
DOIs
Publication statusPublished - 15 Mar 1975

    Research areas

  • baboon, drug-metabolizing enzymes, azo reductase, N-demethylation, O-demethylation, nitroreductase, p-hydroxylation, NADPH cytochrome c reductase, cytochrome P-450, arylsulfatase A and B, beta-glucuronidase, Papio anabis

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