Methylglyoxal Metabolism and Aging-Related Disease: Moving from Correlation toward Causation

Rasmus Kold-Christensen; Mogens Johannsen

doi:10.1016/j.tem.2019.10.003

Methylglyoxal Metabolism and Aging-Related Disease: Moving from Correlation toward Causation

Rasmus Kold-Christensen
, Mogens Johannsen^*

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

100 Citations (Scopus)

Abstract

Methylglyoxal (MG) is a ubiquitous metabolite that spontaneously reacts with biopolymers forming advanced glycation end-products (AGEs). AGEs are strongly associated with aging-related diseases, including cancer, neurodegenerative diseases, and diabetes. As the formation of AGEs is nonenzymatic, the damage caused by MG and AGEs has been regarded as unspecific. This may have resulted in the field generally been regarded as unappealing by many researchers, as detailed mechanisms have been difficult to probe. However, accumulating evidence highlighting the importance of MG in human metabolism and disease, as well as data revealing how MG can elicit its signaling function via specific protein AGEs, could change the current mindset, accelerating the field to the forefront of future research.

Original language	English
Journal	Trends in Endocrinology and Metabolism
Volume	31
Issue	2
Pages (from-to)	81-92
Number of pages	12
ISSN	1043-2760
DOIs	https://doi.org/10.1016/j.tem.2019.10.003
Publication status	Published - 2020

Keywords

AGE
aging-related disease
diabetes
GLO1
hormesis
methylglyoxal

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title = "Methylglyoxal Metabolism and Aging-Related Disease: Moving from Correlation toward Causation",

abstract = "Methylglyoxal (MG) is a ubiquitous metabolite that spontaneously reacts with biopolymers forming advanced glycation end-products (AGEs). AGEs are strongly associated with aging-related diseases, including cancer, neurodegenerative diseases, and diabetes. As the formation of AGEs is nonenzymatic, the damage caused by MG and AGEs has been regarded as unspecific. This may have resulted in the field generally been regarded as unappealing by many researchers, as detailed mechanisms have been difficult to probe. However, accumulating evidence highlighting the importance of MG in human metabolism and disease, as well as data revealing how MG can elicit its signaling function via specific protein AGEs, could change the current mindset, accelerating the field to the forefront of future research.",

keywords = "AGE, aging-related disease, diabetes, GLO1, hormesis, methylglyoxal",

author = "Rasmus Kold-Christensen and Mogens Johannsen",

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language = "English",

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pages = "81--92",

journal = "Trends in Endocrinology and Metabolism",

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publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Methylglyoxal Metabolism and Aging-Related Disease

T2 - Moving from Correlation toward Causation

AU - Kold-Christensen, Rasmus

AU - Johannsen, Mogens

PY - 2020

Y1 - 2020

N2 - Methylglyoxal (MG) is a ubiquitous metabolite that spontaneously reacts with biopolymers forming advanced glycation end-products (AGEs). AGEs are strongly associated with aging-related diseases, including cancer, neurodegenerative diseases, and diabetes. As the formation of AGEs is nonenzymatic, the damage caused by MG and AGEs has been regarded as unspecific. This may have resulted in the field generally been regarded as unappealing by many researchers, as detailed mechanisms have been difficult to probe. However, accumulating evidence highlighting the importance of MG in human metabolism and disease, as well as data revealing how MG can elicit its signaling function via specific protein AGEs, could change the current mindset, accelerating the field to the forefront of future research.

AB - Methylglyoxal (MG) is a ubiquitous metabolite that spontaneously reacts with biopolymers forming advanced glycation end-products (AGEs). AGEs are strongly associated with aging-related diseases, including cancer, neurodegenerative diseases, and diabetes. As the formation of AGEs is nonenzymatic, the damage caused by MG and AGEs has been regarded as unspecific. This may have resulted in the field generally been regarded as unappealing by many researchers, as detailed mechanisms have been difficult to probe. However, accumulating evidence highlighting the importance of MG in human metabolism and disease, as well as data revealing how MG can elicit its signaling function via specific protein AGEs, could change the current mindset, accelerating the field to the forefront of future research.

KW - AGE

KW - aging-related disease

KW - diabetes

KW - GLO1

KW - hormesis

KW - methylglyoxal

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DO - 10.1016/j.tem.2019.10.003

M3 - Review

C2 - 31757593

AN - SCOPUS:85075875058

SN - 1043-2760

VL - 31

SP - 81

EP - 92

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 2

ER -

Methylglyoxal Metabolism and Aging-Related Disease: Moving from Correlation toward Causation

Abstract

Keywords

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