Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula

Ahmed R. Hassan; Salah M. El-Kousy; Sayed A. El-Toumy; Karla Frydenyang; Truong Thanh Tung; Jesper Olsen; John Nielsen; Soren Bragger Christensen

doi:10.1021/acs.jnatprod.7b00106

Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula

Ahmed R. Hassan
, Salah M. El-Kousy
, Sayed A. El-Toumy
, Karla Frydenyang
, Truong Thanh Tung
, Jesper Olsen
, John Nielsen^*
, Soren Bragger Christensen

^*Corresponding author for this work

Department of Physics and Astronomy

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

9 Citations (Scopus)

Abstract

A phytochemical investigation of Seidlitzia rosmarinus collected along the shoreline of the Gulf of Aqaba in the remote southern desert region of the Sinai peninsula has revealed the presence of the registered drug metformin (4). However, analysis of the ¹⁴C content revealed the drug to be an anthropogenic contaminant. Consequently, natural product researchers should be aware that compounds isolated from plants might originate from environmental contamination rather than biosynthesis. The new natural product N-(4-hydroxyphenylethyl)-α-chloroferuloylamide was isolated as a mixture of the E and Z isomers along with a number of other well-established secondary metabolites.

Original language	English
Journal	Journal of Natural Products
Volume	80
Issue	10
Pages (from-to)	2830-2834
Number of pages	5
ISSN	0163-3864
DOIs	https://doi.org/10.1021/acs.jnatprod.7b00106
Publication status	Published - 27 Oct 2017

Keywords

OCCURRING ORGANOHALOGEN COMPOUNDS
NATURAL-PRODUCTS
DRUG METFORMIN
TRAMADOL
AGENTS
DERIVATIVES
FLAVONOIDS
PLANTS

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@article{06bb14ddb3334603848b55b5c20aef66,

title = "Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula",

abstract = "A phytochemical investigation of Seidlitzia rosmarinus collected along the shoreline of the Gulf of Aqaba in the remote southern desert region of the Sinai peninsula has revealed the presence of the registered drug metformin (4). However, analysis of the 14C content revealed the drug to be an anthropogenic contaminant. Consequently, natural product researchers should be aware that compounds isolated from plants might originate from environmental contamination rather than biosynthesis. The new natural product N-(4-hydroxyphenylethyl)-α-chloroferuloylamide was isolated as a mixture of the E and Z isomers along with a number of other well-established secondary metabolites.",

keywords = "OCCURRING ORGANOHALOGEN COMPOUNDS, NATURAL-PRODUCTS, DRUG METFORMIN, TRAMADOL, AGENTS, DERIVATIVES, FLAVONOIDS, PLANTS",

author = "Hassan, \{Ahmed R.\} and El-Kousy, \{Salah M.\} and El-Toumy, \{Sayed A.\} and Karla Frydenyang and \{Truong Thanh Tung\} and Jesper Olsen and John Nielsen and Christensen, \{Soren Bragger\}",

year = "2017",

month = oct,

day = "27",

doi = "10.1021/acs.jnatprod.7b00106",

language = "English",

volume = "80",

pages = "2830--2834",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

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Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula. / Hassan, Ahmed R.; El-Kousy, Salah M.; El-Toumy, Sayed A. et al.
In: Journal of Natural Products, Vol. 80, No. 10, 27.10.2017, p. 2830-2834.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula

AU - Hassan, Ahmed R.

AU - El-Kousy, Salah M.

AU - El-Toumy, Sayed A.

AU - Frydenyang, Karla

AU - Truong Thanh Tung, null

AU - Olsen, Jesper

AU - Nielsen, John

AU - Christensen, Soren Bragger

PY - 2017/10/27

Y1 - 2017/10/27

N2 - A phytochemical investigation of Seidlitzia rosmarinus collected along the shoreline of the Gulf of Aqaba in the remote southern desert region of the Sinai peninsula has revealed the presence of the registered drug metformin (4). However, analysis of the 14C content revealed the drug to be an anthropogenic contaminant. Consequently, natural product researchers should be aware that compounds isolated from plants might originate from environmental contamination rather than biosynthesis. The new natural product N-(4-hydroxyphenylethyl)-α-chloroferuloylamide was isolated as a mixture of the E and Z isomers along with a number of other well-established secondary metabolites.

AB - A phytochemical investigation of Seidlitzia rosmarinus collected along the shoreline of the Gulf of Aqaba in the remote southern desert region of the Sinai peninsula has revealed the presence of the registered drug metformin (4). However, analysis of the 14C content revealed the drug to be an anthropogenic contaminant. Consequently, natural product researchers should be aware that compounds isolated from plants might originate from environmental contamination rather than biosynthesis. The new natural product N-(4-hydroxyphenylethyl)-α-chloroferuloylamide was isolated as a mixture of the E and Z isomers along with a number of other well-established secondary metabolites.

KW - OCCURRING ORGANOHALOGEN COMPOUNDS

KW - NATURAL-PRODUCTS

KW - DRUG METFORMIN

KW - TRAMADOL

KW - AGENTS

KW - DERIVATIVES

KW - FLAVONOIDS

KW - PLANTS

UR - https://www.scopus.com/pages/publications/85032579307

U2 - 10.1021/acs.jnatprod.7b00106

DO - 10.1021/acs.jnatprod.7b00106

M3 - Journal article

C2 - 28930456

SN - 0163-3864

VL - 80

SP - 2830

EP - 2834

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 10

ER -

Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula

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Keywords

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