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Metastasis directed therapy for liver and lung metastases from colorectal cancer - A population based study

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About 10-20% of patients with metastatic colorectal cancer (mCRC) are candidates for metastasis directed therapies such as surgical resection, ablation and stereotactic radiotherapy. We examined the temporal changes in use of metastasis directed therapies and established prognostic factors for survival in a nationwide cohort study. The Danish nationwide medical registries were used to retrieve data on treatment for liver and/or lung metastasis in patients with metastatic colorectal cancer in the period 2000-2013. Overall survival through 2014 was calculated from the time of treatment of metastases by Kaplan-Meier method and mortality between groups was assessed using Cox regression. We report 2912 patients undergoing a total of 3602 procedures with an increased use of all modalities during 14 calendar years. Median survival was 3.7 years (interquartile range (IQR) 2.0-9.7 years). In the multivariate analysis the nodal stage of the primary tumor had the most pronounced association with survival with a hazard ratio for mortality of 1.56 (95% CI: 1.33-1.83) for N2 stage with reference to N0. Furthermore, female gender, age, comorbidity, surgical treatment, administration of chemotherapy and left sided primary tumors were associated with improved prognosis in the multivariate analysis. This article is protected by copyright. All rights reserved.
Original languageEnglish
JournalInternational Journal of Cancer
Pages (from-to)3218-3226
Number of pages9
Publication statusPublished - 15 Dec 2018

    Research areas

  • colorectal cancer, metastasis directed treatment, population-based study, Colorectal Neoplasms/epidemiology, Lung Neoplasms/epidemiology, Humans, Liver Neoplasms/epidemiology, Middle Aged, Kaplan-Meier Estimate, Proportional Hazards Models, Radiosurgery, Male, Denmark/epidemiology, Radiofrequency Ablation, Female, Registries, Aged, Chemotherapy, Adjuvant, Population Surveillance

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