Metabolomic profiling reveals the difference on reproductive performance between high and low lactational weight loss sows

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DOI

  • Liang Hu, Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University
  • ,
  • Lianqiang Che, Sichuan Agricultural University
  • ,
  • Chen Wu, Sichuan Agricultural University
  • ,
  • Mihai Victor Curtasu
  • ,
  • Fali Wu, Sichuan Agricultural University
  • ,
  • Zhengfeng Fang, Sichuan Agricultural University
  • ,
  • Yan Lin, Sichuan Agricultural University
  • ,
  • Shengyu Xu, Sichuan Agricultural University
  • ,
  • Bin Feng, Sichuan Agricultural University
  • ,
  • Jian Li, Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University
  • ,
  • Yong Zhuo, Sichuan Agricultural University
  • ,
  • Peter Kappel Theil
  • De Wu, Sichuan Agricultural University

Sows suffering excess weight loss during lactation may delay weaning to estrus interval (WEI) and have a detrimental effect on subsequent reproductive performance, however, the underlying mechanism is not completely clear. Therefore, the goal of this study was to investigate physiological profiles manifested in plasma originating from high (HWL) and low lactational weight loss (LWL) sows. The plasma biochemical parameters, hormones, antioxidant parameters, and milk compositions were assessed. Furthermore, plasma metabolites were analyzed using ultrahigh-performance liquid chromatography/time-of-flight mass spectrometry in positive and negative ion modes. Results showed that HWL sows had a lower feed intake and higher lactational weight loss and prolonged WEI, but had similar litter performance and milk composition compared to LWL sows. These changes were associated with lower plasma insulin-like growth factor 1 and higher fibroblast growth factor 21 levels in the HWL sows. Moreover, HWL led to a severe oxidative stress and metabolic damage, as accompanied by excessive protein breakdown and lipids mobilization at weaning. Metabolomic analysis revealed differences in 46 compounds between HWL and LWL sows, and the identified compounds were enriched in metabolic pathways related to amino acids metabolism, fatty acids oxidation metabolism, bile acids biosynthesis, and nucleoside metabolism. These results provide the evidence for physiological mechanism in sows with excessive lactational weight loss that delayed the WEI. Metabolomic data provides essential information and gives rise to potential targets for the development of nutritional intervention strategies.

Original languageEnglish
Article number295
JournalMetabolites
Volume9
Issue12
ISSN2218-1989
DOIs
Publication statusPublished - Dec 2019

    Research areas

  • Lactational weight loss, Metabolites, Oxidative stress, Reproductive performance, Sow

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