Metabolism of dimethylnitrosamine and 1,2-dimethylhydrazine in cultured human bronchi

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  • Curtis C. Harris, United States
  • Herman Autrup, Human Tissue Studies Section, Experimental Pathology Branch, Division of Cancer Cause and Prevention, NCI, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Maryland, Denmark
  • Gary D. Stoner, United States
  • Elizabeth M. McDowell, United States
  • Benjamin F. Trump, United States
  • Paul Schafer, United States
  • Institute of Environmental and Occupational Medicine
The metabolic activation of several chemical classes of procarcinogens is being studied in cultured human bronchi. Previous studies have shown that carcinogenic polynuclear aromatic hydrocarbons are metabolically activated by
the bronchial epithelium. In the study reported here, dimethylnitrosamine and 1,2-dimethylhydrazine were also found to bind to both cellular DNA and protein. Bronchial DMA was methylated in both the O-6 and N-7 positions of guanine. In addition to polynuclear aromatic hydrocarbons, an aliphatic nitrosamine and a methylhydrazine can now be added to the list of xenobiotic chemical carcinogens metabolized by human bronchus.
Original languageEnglish
JournalCancer Research
Pages (from-to)2309-2311
Number of pages3
Publication statusPublished - Jul 1977

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