Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Francis J McMahon
  • ,
  • Nirmala Akula
  • ,
  • Thomas G Schulze
  • ,
  • Pierandrea Muglia
  • ,
  • Federica Tozzi
  • ,
  • Sevilla D Detera-Wadleigh
  • ,
  • C J M Steele
  • ,
  • René Breuer
  • ,
  • Jana Strohmaier
  • ,
  • Jens R Wendland
  • ,
  • Manuel Mattheisen
  • Thomas W Mühleisen
  • ,
  • Wolfgang Maier
  • ,
  • Markus M Nöthen
  • ,
  • Sven Cichon
  • ,
  • Anne Farmer
  • ,
  • John B Vincent
  • ,
  • Florian Holsboer
  • ,
  • Martin Preisig
  • ,
  • Marcella Rietschel
  • ,
  • Bipolar Disorder Genome Study (BiGS) Consortium
The major mood disorders, which include bipolar disorder and major depressive disorder (MDD), are considered heritable traits, although previous genetic association studies have had limited success in robustly identifying risk loci. We performed a meta-analysis of five case-control cohorts for major mood disorder, including over 13,600 individuals genotyped on high-density SNP arrays. We identified SNPs at 3p21.1 associated with major mood disorders (rs2251219, P = 3.63 x 10(-8); odds ratio = 0.87; 95% confidence interval, 0.83-0.92), with supportive evidence for association observed in two out of three independent replication cohorts. These results provide an example of a shared genetic susceptibility locus for bipolar disorder and MDD.
Original languageEnglish
JournalNature Genetics
Volume42
Issue2
Pages (from-to)128-31
Number of pages4
ISSN1061-4036
DOIs
Publication statusPublished - Feb 2010
Externally publishedYes

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