Mesoscale simulations: An indispensable approach to understand biomembranes

TY - JOUR

T1 - Mesoscale simulations

T2 - An indispensable approach to understand biomembranes

AU - Duncan, Anna L.

AU - Pezeshkian, Weria

N1 - Publisher Copyright: © 2023 Biophysical Society

PY - 2023/6

Y1 - 2023/6

N2 - Computer simulation techniques form a versatile tool, a computational microscope, for exploring biological processes. This tool has been particularly effective in exploring different features of biological membranes. In recent years, thanks to elegant multiscale simulation schemes, some fundamental limitations of investigations by distinct simulation techniques have been resolved. As a result, we are now capable of exploring processes spanning multiple scales beyond the capacity of any single technique. In this perspective, we argue that mesoscale simulations require more attention and must be further developed to fill evident gaps in a quest toward simulating and modeling living cell membranes.

AB - Computer simulation techniques form a versatile tool, a computational microscope, for exploring biological processes. This tool has been particularly effective in exploring different features of biological membranes. In recent years, thanks to elegant multiscale simulation schemes, some fundamental limitations of investigations by distinct simulation techniques have been resolved. As a result, we are now capable of exploring processes spanning multiple scales beyond the capacity of any single technique. In this perspective, we argue that mesoscale simulations require more attention and must be further developed to fill evident gaps in a quest toward simulating and modeling living cell membranes.

UR - http://www.scopus.com/inward/record.url?scp=85150266267&partnerID=8YFLogxK

U2 - 10.1016/j.bpj.2023.02.017

DO - 10.1016/j.bpj.2023.02.017

M3 - Review

C2 - 36809878

AN - SCOPUS:85150266267

SN - 0006-3495

VL - 122

SP - 1883

EP - 1889

JO - Biophysical Journal

JF - Biophysical Journal

IS - 11

ER -