TY - JOUR
T1 - Membrane supply and remodeling during autophagosome biogenesis
AU - Gómez-Sánchez, Rubén
AU - Tooze, Sharon A
AU - Reggiori, Fulvio
N1 - Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.
PY - 2021/8
Y1 - 2021/8
N2 - The de novo generation of double-membrane autophagosomes is the hallmark of autophagy. The initial membranous precursor cisterna, the phagophore, is very likely generated by the fusion of vesicles and acts as a membrane seed for the subsequent expansion into an autophagosome. This latter step requires a massive convoy of lipids into the phagophore. In this review, we present recent advances in our understanding of the intracellular membrane sources and lipid delivery mechanisms, which principally rely on vesicular transport and membrane contact sites that contribute to autophagosome biogenesis. In this context, we discuss lipid biosynthesis and lipid remodeling events that play a crucial role in both phagophore nucleation and expansion.
AB - The de novo generation of double-membrane autophagosomes is the hallmark of autophagy. The initial membranous precursor cisterna, the phagophore, is very likely generated by the fusion of vesicles and acts as a membrane seed for the subsequent expansion into an autophagosome. This latter step requires a massive convoy of lipids into the phagophore. In this review, we present recent advances in our understanding of the intracellular membrane sources and lipid delivery mechanisms, which principally rely on vesicular transport and membrane contact sites that contribute to autophagosome biogenesis. In this context, we discuss lipid biosynthesis and lipid remodeling events that play a crucial role in both phagophore nucleation and expansion.
KW - Autophagosomes
KW - Autophagy
KW - Intracellular Membranes
UR - http://www.scopus.com/inward/record.url?scp=85105832123&partnerID=8YFLogxK
U2 - 10.1016/j.ceb.2021.02.001
DO - 10.1016/j.ceb.2021.02.001
M3 - Review
C2 - 33930785
SN - 0955-0674
VL - 71
SP - 112
EP - 119
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
ER -