Membrane supply and remodeling during autophagosome biogenesis

Rubén Gómez-Sánchez; Sharon A Tooze; Fulvio Reggiori

doi:10.1016/j.ceb.2021.02.001

Membrane supply and remodeling during autophagosome biogenesis

Rubén Gómez-Sánchez, Sharon A Tooze, Fulvio Reggiori

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

60 Citations (Scopus)

Abstract

The de novo generation of double-membrane autophagosomes is the hallmark of autophagy. The initial membranous precursor cisterna, the phagophore, is very likely generated by the fusion of vesicles and acts as a membrane seed for the subsequent expansion into an autophagosome. This latter step requires a massive convoy of lipids into the phagophore. In this review, we present recent advances in our understanding of the intracellular membrane sources and lipid delivery mechanisms, which principally rely on vesicular transport and membrane contact sites that contribute to autophagosome biogenesis. In this context, we discuss lipid biosynthesis and lipid remodeling events that play a crucial role in both phagophore nucleation and expansion.

Original language	English
Journal	Current Opinion in Cell Biology
Volume	71
Pages (from-to)	112-119
Number of pages	8
ISSN	0955-0674
DOIs	https://doi.org/10.1016/j.ceb.2021.02.001
Publication status	Published - Aug 2021
Externally published	Yes

Keywords

Autophagosomes
Autophagy
Intracellular Membranes

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title = "Membrane supply and remodeling during autophagosome biogenesis",

abstract = "The de novo generation of double-membrane autophagosomes is the hallmark of autophagy. The initial membranous precursor cisterna, the phagophore, is very likely generated by the fusion of vesicles and acts as a membrane seed for the subsequent expansion into an autophagosome. This latter step requires a massive convoy of lipids into the phagophore. In this review, we present recent advances in our understanding of the intracellular membrane sources and lipid delivery mechanisms, which principally rely on vesicular transport and membrane contact sites that contribute to autophagosome biogenesis. In this context, we discuss lipid biosynthesis and lipid remodeling events that play a crucial role in both phagophore nucleation and expansion.",

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year = "2021",

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AU - Gómez-Sánchez, Rubén

AU - Tooze, Sharon A

AU - Reggiori, Fulvio

PY - 2021/8

Y1 - 2021/8

N2 - The de novo generation of double-membrane autophagosomes is the hallmark of autophagy. The initial membranous precursor cisterna, the phagophore, is very likely generated by the fusion of vesicles and acts as a membrane seed for the subsequent expansion into an autophagosome. This latter step requires a massive convoy of lipids into the phagophore. In this review, we present recent advances in our understanding of the intracellular membrane sources and lipid delivery mechanisms, which principally rely on vesicular transport and membrane contact sites that contribute to autophagosome biogenesis. In this context, we discuss lipid biosynthesis and lipid remodeling events that play a crucial role in both phagophore nucleation and expansion.

AB - The de novo generation of double-membrane autophagosomes is the hallmark of autophagy. The initial membranous precursor cisterna, the phagophore, is very likely generated by the fusion of vesicles and acts as a membrane seed for the subsequent expansion into an autophagosome. This latter step requires a massive convoy of lipids into the phagophore. In this review, we present recent advances in our understanding of the intracellular membrane sources and lipid delivery mechanisms, which principally rely on vesicular transport and membrane contact sites that contribute to autophagosome biogenesis. In this context, we discuss lipid biosynthesis and lipid remodeling events that play a crucial role in both phagophore nucleation and expansion.

KW - Autophagosomes

KW - Autophagy

KW - Intracellular Membranes

UR - http://www.scopus.com/inward/record.url?scp=85105832123&partnerID=8YFLogxK

U2 - 10.1016/j.ceb.2021.02.001

DO - 10.1016/j.ceb.2021.02.001

M3 - Review

C2 - 33930785

SN - 0955-0674

VL - 71

SP - 112

EP - 119

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

ER -

Membrane supply and remodeling during autophagosome biogenesis

Abstract

Keywords

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