Membrane Contact Sites in Autophagy

Emma Zwilling, Fulvio Reggiori*

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

5 Citations (Scopus)

Abstract

Eukaryotes utilize different communication strategies to coordinate processes between different cellular compartments either indirectly, through vesicular transport, or directly, via membrane contact sites (MCSs). MCSs have been implicated in lipid metabolism, calcium signaling and the regulation of organelle biogenesis in various cell types. Several studies have shown that MCSs play a crucial role in the regulation of macroautophagy, an intracellular catabolic transport route that is characterized by the delivery of cargoes (proteins, protein complexes or aggregates, organelles and pathogens) to yeast and plant vacuoles or mammalian lysosomes, for their degradation and recycling into basic metabolites. Macroautophagy is characterized by the de novo formation of double-membrane vesicles called autophagosomes, and their biogenesis requires an enormous amount of lipids. MCSs appear to have a central role in this supply, as well as in the organization of the autophagy-related (ATG) machinery. In this review, we will summarize the evidence for the participation of specific MCSs in autophagosome formation, with a focus on the budding yeast and mammalian systems.

Original languageEnglish
Article number3813
JournalCells
Volume11
Issue23
Number of pages16
ISSN2073-4409
DOIs
Publication statusPublished - Dec 2022

Keywords

  • MAMs
  • autophagosome
  • endoplasmic reticulum
  • lipid droplets
  • lipid transfer
  • mitochondria
  • phagophore
  • plasma membrane
  • vacuole

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