Mechanisms, Methods of Tracking and Applications of DNA Walkers: A Review

Julian Valero*, Marko Skugor

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

Abstract

In recent years, DNA nanotechnology expanded its scope from structural DNA nanoarchitecture towards designing dynamic and functional nanodevices. This progress has been evident in the development of an advanced class of DNA nanomachines, the so-called DNA walkers. They represent an evolution of basic switching between distinctly defined states into continuous motion. Inspired by the naturally occurring walkers such as kinesin, research on DNA walkers has focused on developing new ways of powering them and investigating their walking mechanisms and advantages. New techniques allowing the visualization of walkers as single molecules and in real time have provided a deeper insight into their behavior and performance. The construction of novel DNA walkers bears great potential for applications in therapeutics, nanorobotics or computation. This review will cover the various examples and breakthrough designs of recently reported DNA walkers that pushed the limits of their performance. It will also mention the techniques that have been used to investigate walker nanosystems, as well as discuss the applications that have been explored so far.

Original languageEnglish
JournalChemPhysChem
Volume21
Issue17
Pages (from-to)1971-1988
Number of pages18
ISSN1439-4235
DOIs
Publication statusPublished - Sept 2020

Keywords

  • DNA structures
  • DNA walker
  • fluorescence spectroscopy
  • molecular devices
  • nanotechnology
  • SMALL-MOLECULE
  • DESIGN PRINCIPLES
  • AUTONOMOUS DNA
  • WALKING
  • MOTOR
  • KINESIN
  • TRANSPORT
  • DYNAMICS
  • MOTIONS
  • DEVICES

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