Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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TY - JOUR
T1 - Meat and heme iron intake and esophageal adenocarcinoma the European Prospective investigation into Cancer and Nutrition study
AU - Jakszyn, Paula
AU - Luján-Barroso, Leila
AU - Agudo, Antonio
AU - Bueno-de-Mesquita, H Bas
AU - Molina, Esther
AU - Sánchez, M José
AU - Fonseca-Nunes, Ana
AU - Siersema, Peter D
AU - Matiello, Amalia
AU - Tumino, Rosario
AU - Saieva, Calogero
AU - Pala, Valeria
AU - Vineis, Paolo
AU - Boutron-Ruault, Marie-Christine
AU - Racine, Antoine
AU - Bastide, Nadie
AU - Travis, Ruth C
AU - Khaw, Kay-Tee
AU - Riboli, Elio
AU - Murphy, Neil
AU - Vergnaud, Anne-Claire
AU - Trichopoulou, Antonia
AU - Valanou, Elissavet
AU - Oikonomidou, Despina
AU - Weiderpass, Elisabete
AU - Skeie, Guri
AU - Johansen, Dorthe
AU - Lindkvist, Björn
AU - Johansson, Mattias
AU - Duarte-Salles, Talita
AU - Freisling, Heinz
AU - Barricarte, Aurelio
AU - Huerta, Jose M
AU - Amiano, Pilar
AU - Tjonneland, Anne
AU - Overvad, Kim
AU - Kuehn, Tilman
AU - Grote, Verena
AU - Boeing, Heiner
AU - Peeters, Petra Hm
AU - González, Carlos A
N1 - Copyright © 2013 UICC.
PY - 2013/12/1
Y1 - 2013/12/1
N2 - Although recent studies suggest that high intakes of meat and heme iron are risk factors for several types of cancer, studies in relation to esophageal adenocarcinoma (EAC) are scarce. Previous results in the European Prospective Investigation into Cancer and Nutrition (EPIC) based on a relatively small number of cases suggested a positive association between processed meat and EAC. In this study we investigate the association between intake of different types of meats as well as heme iron intake, and EAC risk in a larger number of cases from EPIC. The study included 481,419 individuals and 137 incident cases of EAC that occurred during an average of 11 years of follow-up. Dietary intake of meat (unprocessed/processed red and white meat) was assessed by validated center-specific questionnaires. Heme iron was calculated as a type-specific percentage of the total iron content in meat. After adjusting for relevant confounders we observed a statistically significant positive association of EAC risk with heme iron and processed meat intake, with HR: 1.67, 95% CI: 1.05-2.68 and HR: 2.27, 95% CI:1.33-3.89 respectively for comparison of the highest vs. lowest tertile of intake Our results suggest a potential association between higher intakes of processed meat and heme iron and risk of EAC. © 2013 Wiley Periodicals, Inc.
AB - Although recent studies suggest that high intakes of meat and heme iron are risk factors for several types of cancer, studies in relation to esophageal adenocarcinoma (EAC) are scarce. Previous results in the European Prospective Investigation into Cancer and Nutrition (EPIC) based on a relatively small number of cases suggested a positive association between processed meat and EAC. In this study we investigate the association between intake of different types of meats as well as heme iron intake, and EAC risk in a larger number of cases from EPIC. The study included 481,419 individuals and 137 incident cases of EAC that occurred during an average of 11 years of follow-up. Dietary intake of meat (unprocessed/processed red and white meat) was assessed by validated center-specific questionnaires. Heme iron was calculated as a type-specific percentage of the total iron content in meat. After adjusting for relevant confounders we observed a statistically significant positive association of EAC risk with heme iron and processed meat intake, with HR: 1.67, 95% CI: 1.05-2.68 and HR: 2.27, 95% CI:1.33-3.89 respectively for comparison of the highest vs. lowest tertile of intake Our results suggest a potential association between higher intakes of processed meat and heme iron and risk of EAC. © 2013 Wiley Periodicals, Inc.
U2 - 10.1002/ijc.28291
DO - 10.1002/ijc.28291
M3 - Journal article
C2 - 23728954
VL - 133
SP - 2744
EP - 2750
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 11
ER -