Maternal thyroid disease in pregnancy and timing of pubertal development in sons and daughters

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Maternal thyroid disease in pregnancy and timing of pubertal development in sons and daughters. / Lunddorf, Lea L H; Ernst, Andreas; Brix, Nis et al.

In: Fertility and Sterility, Vol. 118, No. 1, 07.2022, p. 136-146.

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@article{3b05a73208914e18a0307467ad41b48a,
title = "Maternal thyroid disease in pregnancy and timing of pubertal development in sons and daughters",
abstract = "OBJECTIVE: To study whether maternal thyroid disease in pregnancy is associated with pubertal timing in sons and daughters.DESIGN: Cohort study.SETTING: National birth cohort and health registers.PATIENT(S): A total of 15,763 mothers and children from the Danish National Birth Cohort and its Puberty Cohort.INTERVENTION(S): Register-based and self-reported information on maternal thyroid diseases during pregnancy (hyperthyroidism, hypothyroidism, benign goiter, or no thyroid disease [reference group]).MAIN OUTCOME MEASURE(S): The adjusted mean age difference (months) at attaining several self-reported pubertal milestones collected every 6 months using an interval-censored regression and the average difference in age at attaining all pubertal milestones using the Huber-White robust variance estimation (primary outcome).RESULT(S): Sons of mothers with hyperthyroidism had earlier pubertal development (average difference, -2.9 [95% confidence interval (CI), -5.0 to -0.7] months) than unexposed sons. Maternal hypothyroidism was not associated with pubertal development in sons (average difference, -1.2 [95% CI, -5.1 to 2.7] months). We observed nonstatistically significant indications of earlier pubertal development in sons of mothers with benign goiter (average difference, -1.9 [95% CI, -4.6 to 0.9] months). Maternal thyroid disease was not associated with pubertal development in daughters (average difference (months), hyperthyroidism, -0.8 [95% CI, -2.8 to 1.2]; hypothyroidism, 0.3 [95% CI, -3.1 to 3.8]; and benign goiter, 0.7 [95% CI, -2.0 to 3.4]).CONCLUSION(S): We found indications of earlier pubertal development in sons of mothers with hyperthyroidism. More research is needed to further investigate the observed sex-specific association.",
keywords = "puberty, fetal programming, hyperthyroidism, goiter",
author = "Lunddorf, {Lea L H} and Andreas Ernst and Nis Brix and Arendt, {Linn H} and Andersen, {Stine L} and J{\o}rn Olsen and Ramlau-Hansen, {Cecilia H}",
year = "2022",
month = jul,
doi = "10.1016/j.fertnstert.2022.03.018",
language = "English",
volume = "118",
pages = "136--146",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "Elsevier Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Maternal thyroid disease in pregnancy and timing of pubertal development in sons and daughters

AU - Lunddorf, Lea L H

AU - Ernst, Andreas

AU - Brix, Nis

AU - Arendt, Linn H

AU - Andersen, Stine L

AU - Olsen, Jørn

AU - Ramlau-Hansen, Cecilia H

PY - 2022/7

Y1 - 2022/7

N2 - OBJECTIVE: To study whether maternal thyroid disease in pregnancy is associated with pubertal timing in sons and daughters.DESIGN: Cohort study.SETTING: National birth cohort and health registers.PATIENT(S): A total of 15,763 mothers and children from the Danish National Birth Cohort and its Puberty Cohort.INTERVENTION(S): Register-based and self-reported information on maternal thyroid diseases during pregnancy (hyperthyroidism, hypothyroidism, benign goiter, or no thyroid disease [reference group]).MAIN OUTCOME MEASURE(S): The adjusted mean age difference (months) at attaining several self-reported pubertal milestones collected every 6 months using an interval-censored regression and the average difference in age at attaining all pubertal milestones using the Huber-White robust variance estimation (primary outcome).RESULT(S): Sons of mothers with hyperthyroidism had earlier pubertal development (average difference, -2.9 [95% confidence interval (CI), -5.0 to -0.7] months) than unexposed sons. Maternal hypothyroidism was not associated with pubertal development in sons (average difference, -1.2 [95% CI, -5.1 to 2.7] months). We observed nonstatistically significant indications of earlier pubertal development in sons of mothers with benign goiter (average difference, -1.9 [95% CI, -4.6 to 0.9] months). Maternal thyroid disease was not associated with pubertal development in daughters (average difference (months), hyperthyroidism, -0.8 [95% CI, -2.8 to 1.2]; hypothyroidism, 0.3 [95% CI, -3.1 to 3.8]; and benign goiter, 0.7 [95% CI, -2.0 to 3.4]).CONCLUSION(S): We found indications of earlier pubertal development in sons of mothers with hyperthyroidism. More research is needed to further investigate the observed sex-specific association.

AB - OBJECTIVE: To study whether maternal thyroid disease in pregnancy is associated with pubertal timing in sons and daughters.DESIGN: Cohort study.SETTING: National birth cohort and health registers.PATIENT(S): A total of 15,763 mothers and children from the Danish National Birth Cohort and its Puberty Cohort.INTERVENTION(S): Register-based and self-reported information on maternal thyroid diseases during pregnancy (hyperthyroidism, hypothyroidism, benign goiter, or no thyroid disease [reference group]).MAIN OUTCOME MEASURE(S): The adjusted mean age difference (months) at attaining several self-reported pubertal milestones collected every 6 months using an interval-censored regression and the average difference in age at attaining all pubertal milestones using the Huber-White robust variance estimation (primary outcome).RESULT(S): Sons of mothers with hyperthyroidism had earlier pubertal development (average difference, -2.9 [95% confidence interval (CI), -5.0 to -0.7] months) than unexposed sons. Maternal hypothyroidism was not associated with pubertal development in sons (average difference, -1.2 [95% CI, -5.1 to 2.7] months). We observed nonstatistically significant indications of earlier pubertal development in sons of mothers with benign goiter (average difference, -1.9 [95% CI, -4.6 to 0.9] months). Maternal thyroid disease was not associated with pubertal development in daughters (average difference (months), hyperthyroidism, -0.8 [95% CI, -2.8 to 1.2]; hypothyroidism, 0.3 [95% CI, -3.1 to 3.8]; and benign goiter, 0.7 [95% CI, -2.0 to 3.4]).CONCLUSION(S): We found indications of earlier pubertal development in sons of mothers with hyperthyroidism. More research is needed to further investigate the observed sex-specific association.

KW - puberty

KW - fetal programming

KW - hyperthyroidism

KW - goiter

UR - http://www.scopus.com/inward/record.url?scp=85130324466&partnerID=8YFLogxK

U2 - 10.1016/j.fertnstert.2022.03.018

DO - 10.1016/j.fertnstert.2022.03.018

M3 - Journal article

C2 - 35568525

VL - 118

SP - 136

EP - 146

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 1

ER -