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Maternal Separation Followed by Chronic Mild Stress in Adulthood Is Associated with Concerted Epigenetic Regulation of AP-1 Complex Genes

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Maternal Separation Followed by Chronic Mild Stress in Adulthood Is Associated with Concerted Epigenetic Regulation of AP-1 Complex Genes. / Donovan, Lene Lundgaard; Henningsen, Kim; Kristensen, Anne Flou; Wiborg, Ove; Nieland, John Dirk; Lichota, Jacek.

In: Journal of Personalized Medicine, Vol. 11, No. 3, 209, 03.2021.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Donovan, LL, Henningsen, K, Kristensen, AF, Wiborg, O, Nieland, JD & Lichota, J 2021, 'Maternal Separation Followed by Chronic Mild Stress in Adulthood Is Associated with Concerted Epigenetic Regulation of AP-1 Complex Genes', Journal of Personalized Medicine, vol. 11, no. 3, 209. https://doi.org/10.3390/jpm11030209

APA

Donovan, L. L., Henningsen, K., Kristensen, A. F., Wiborg, O., Nieland, J. D., & Lichota, J. (2021). Maternal Separation Followed by Chronic Mild Stress in Adulthood Is Associated with Concerted Epigenetic Regulation of AP-1 Complex Genes. Journal of Personalized Medicine, 11(3), [209]. https://doi.org/10.3390/jpm11030209

CBE

MLA

Vancouver

Author

Donovan, Lene Lundgaard ; Henningsen, Kim ; Kristensen, Anne Flou ; Wiborg, Ove ; Nieland, John Dirk ; Lichota, Jacek. / Maternal Separation Followed by Chronic Mild Stress in Adulthood Is Associated with Concerted Epigenetic Regulation of AP-1 Complex Genes. In: Journal of Personalized Medicine. 2021 ; Vol. 11, No. 3.

Bibtex

@article{866518be81ad4dfd982ced6fcb5d2ade,
title = "Maternal Separation Followed by Chronic Mild Stress in Adulthood Is Associated with Concerted Epigenetic Regulation of AP-1 Complex Genes",
abstract = "Depression is one of the most prevalent mental diseases worldwide. Patients with psychiatric diseases often have a history of childhood neglect, indicating that early-life experiences predispose to psychiatric diseases in adulthood. Two strong models were used in the present study: the maternal separation/early deprivation model (MS) and the chronic mild stress model (CMS). In both models, we found changes in the expression of a number of genes such as Creb and Npy. Strikingly, there was a clear regulation of expression of four genes involved in the AP-1 complex: c-Fos, c-Jun, FosB, and Jun-B. Interestingly, different expression levels were observed depending on the model, whereas the combination of the models resulted in a normal level of gene expression. The effects of MS and CMS on gene expression were associated with distinct histone methylation/acetylation patterns of all four genes. The epigenetic changes, like gene expression, were also dependent on the specific stressor or their combination. The obtained results suggest that single life events leave a mark on gene expression and the epigenetic signature of gene promoters, but a combination of different stressors at different life stages can further change gene expression through epigenetic factors, possibly causing the long-lasting adverse effects of stress.",
keywords = "depression, epigenetics, maternal separation, chronic mild stress",
author = "Donovan, {Lene Lundgaard} and Kim Henningsen and Kristensen, {Anne Flou} and Ove Wiborg and Nieland, {John Dirk} and Jacek Lichota",
year = "2021",
month = mar,
doi = "10.3390/jpm11030209",
language = "English",
volume = "11",
journal = "Journal of Personalized Medicine",
issn = "2075-4426",
publisher = "MDPI",
number = "3",

}

RIS

TY - JOUR

T1 - Maternal Separation Followed by Chronic Mild Stress in Adulthood Is Associated with Concerted Epigenetic Regulation of AP-1 Complex Genes

AU - Donovan, Lene Lundgaard

AU - Henningsen, Kim

AU - Kristensen, Anne Flou

AU - Wiborg, Ove

AU - Nieland, John Dirk

AU - Lichota, Jacek

PY - 2021/3

Y1 - 2021/3

N2 - Depression is one of the most prevalent mental diseases worldwide. Patients with psychiatric diseases often have a history of childhood neglect, indicating that early-life experiences predispose to psychiatric diseases in adulthood. Two strong models were used in the present study: the maternal separation/early deprivation model (MS) and the chronic mild stress model (CMS). In both models, we found changes in the expression of a number of genes such as Creb and Npy. Strikingly, there was a clear regulation of expression of four genes involved in the AP-1 complex: c-Fos, c-Jun, FosB, and Jun-B. Interestingly, different expression levels were observed depending on the model, whereas the combination of the models resulted in a normal level of gene expression. The effects of MS and CMS on gene expression were associated with distinct histone methylation/acetylation patterns of all four genes. The epigenetic changes, like gene expression, were also dependent on the specific stressor or their combination. The obtained results suggest that single life events leave a mark on gene expression and the epigenetic signature of gene promoters, but a combination of different stressors at different life stages can further change gene expression through epigenetic factors, possibly causing the long-lasting adverse effects of stress.

AB - Depression is one of the most prevalent mental diseases worldwide. Patients with psychiatric diseases often have a history of childhood neglect, indicating that early-life experiences predispose to psychiatric diseases in adulthood. Two strong models were used in the present study: the maternal separation/early deprivation model (MS) and the chronic mild stress model (CMS). In both models, we found changes in the expression of a number of genes such as Creb and Npy. Strikingly, there was a clear regulation of expression of four genes involved in the AP-1 complex: c-Fos, c-Jun, FosB, and Jun-B. Interestingly, different expression levels were observed depending on the model, whereas the combination of the models resulted in a normal level of gene expression. The effects of MS and CMS on gene expression were associated with distinct histone methylation/acetylation patterns of all four genes. The epigenetic changes, like gene expression, were also dependent on the specific stressor or their combination. The obtained results suggest that single life events leave a mark on gene expression and the epigenetic signature of gene promoters, but a combination of different stressors at different life stages can further change gene expression through epigenetic factors, possibly causing the long-lasting adverse effects of stress.

KW - depression

KW - epigenetics

KW - maternal separation

KW - chronic mild stress

U2 - 10.3390/jpm11030209

DO - 10.3390/jpm11030209

M3 - Journal article

C2 - 33809485

VL - 11

JO - Journal of Personalized Medicine

JF - Journal of Personalized Medicine

SN - 2075-4426

IS - 3

M1 - 209

ER -