Maternal hypothyroidism in the perinatal period and childhood asthma in the offspring

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Maternal hypothyroidism in the perinatal period and childhood asthma in the offspring. / Liu, Xiaoqin ; Andersen, Stine Linding ; Olsen, Jørn et al.
In: Allergy: European Journal of Allergy and Clinical Immunology, Supplement, Vol. 73, No. 4, 04.2018, p. 932-939.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Vancouver

Liu X , Andersen SL , Olsen J , Agerbo E , Schlünssen V, Dharmage SC et al. Maternal hypothyroidism in the perinatal period and childhood asthma in the offspring. Allergy: European Journal of Allergy and Clinical Immunology, Supplement. 2018 Apr;73(4):932-939. Epub 2017 Nov 21. doi: 10.1111/all.13365

Author

Liu, Xiaoqin ; Andersen, Stine Linding ; Olsen, Jørn et al. / Maternal hypothyroidism in the perinatal period and childhood asthma in the offspring. In: Allergy: European Journal of Allergy and Clinical Immunology, Supplement. 2018 ; Vol. 73, No. 4. pp. 932-939.

Bibtex

@article{2ef881f23dea4acf8772d1d8700386b0,

title = "Maternal hypothyroidism in the perinatal period and childhood asthma in the offspring",

abstract = "Background: There is increasing interest in the possible link between maternal hypothyroidism in the perinatal period and childhood asthma risk. We explored this in this study while accounting for the timing of hypothyroidism diagnosis. Further, we evaluated whether the risk was moderated by thyroid hormone treatment during pregnancy. Methods: We conducted a population-based cohort study using Danish national registers. All live-born singletons in Denmark from 1998 to 2007 were identified. Maternal hypothyroidism and asthma in the children were defined by data from the Patient Register and Prescription Registry. We estimated incidence rate ratios (IRRs) of asthma among children born to hypothyroid mothers versus children born to mothers with no recorded thyroid dysfunction using Poisson regression models. Results: Of 595 669 children, 3524 children were born to mothers with hypothyroidism diagnosed before delivery and 4664 diagnosed after delivery. Overall, 48 990 children received treatment for asthma. The IRRs of asthma was 1.16 (95% confidence interval (CI): 1.03-1.30) and 1.12 (95% CI: 1.02-1.24) for children born to mothers with hypothyroidism diagnosed before and after delivery, compared to children born to mothers with no thyroid dysfunction. The highest risk was observed among children born to mothers with hypothyroidism diagnosed before delivery who did not receive thyroid hormone treatment during pregnancy (IRR=1.37, 95% CI: 1.04-1.80). Conclusion: Our findings suggest that maternal hypothyroidism, especially when it is untreated, increases childhood asthma risk. Early detection and appropriate treatment of hypothyroidism in pregnant women may be an area for possible prevention of childhood asthma.",

keywords = "Journal Article, cohort study, childhood, hypothyroidism, perinatal, asthma, MANAGEMENT, THYROID-FUNCTION, RISK, MATURATION, CHILDREN, WOMEN, SUBCLINICAL HYPOTHYROIDISM, DYSFUNCTION, PREGNANCY OUTCOMES, DANISH NATIONWIDE COHORT, Humans, Child, Preschool, Hypothyroidism/epidemiology, Young Adult, Pregnancy Complications/epidemiology, Adult, Female, Child, Prenatal Exposure Delayed Effects/epidemiology, Risk Factors, Pregnancy, Asthma/epidemiology, Cohort Studies",

author = "Xiaoqin Liu and Andersen, {Stine Linding} and J{\o}rn Olsen and Esben Agerbo and Vivi Schl{\"u}nssen and Dharmage, {Shyamali Chandrika} and Trine Munk-Olsen",

note = "{\textcopyright} 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.",

year = "2018",

month = apr,

doi = "10.1111/all.13365",

language = "English",

volume = "73",

pages = "932--939",

journal = "Allergy: European Journal of Allergy and Clinical Immunology, Supplement",

issn = "0108-1675",

publisher = "Wiley-Blackwell Publishing Ltd.",

number = "4",

}

RIS

TY - JOUR

T1 - Maternal hypothyroidism in the perinatal period and childhood asthma in the offspring

AU - Liu, Xiaoqin

AU - Andersen, Stine Linding

AU - Olsen, Jørn

AU - Agerbo, Esben

AU - Schlünssen, Vivi

AU - Dharmage, Shyamali Chandrika

AU - Munk-Olsen, Trine

PY - 2018/4

Y1 - 2018/4

N2 - Background: There is increasing interest in the possible link between maternal hypothyroidism in the perinatal period and childhood asthma risk. We explored this in this study while accounting for the timing of hypothyroidism diagnosis. Further, we evaluated whether the risk was moderated by thyroid hormone treatment during pregnancy. Methods: We conducted a population-based cohort study using Danish national registers. All live-born singletons in Denmark from 1998 to 2007 were identified. Maternal hypothyroidism and asthma in the children were defined by data from the Patient Register and Prescription Registry. We estimated incidence rate ratios (IRRs) of asthma among children born to hypothyroid mothers versus children born to mothers with no recorded thyroid dysfunction using Poisson regression models. Results: Of 595 669 children, 3524 children were born to mothers with hypothyroidism diagnosed before delivery and 4664 diagnosed after delivery. Overall, 48 990 children received treatment for asthma. The IRRs of asthma was 1.16 (95% confidence interval (CI): 1.03-1.30) and 1.12 (95% CI: 1.02-1.24) for children born to mothers with hypothyroidism diagnosed before and after delivery, compared to children born to mothers with no thyroid dysfunction. The highest risk was observed among children born to mothers with hypothyroidism diagnosed before delivery who did not receive thyroid hormone treatment during pregnancy (IRR=1.37, 95% CI: 1.04-1.80). Conclusion: Our findings suggest that maternal hypothyroidism, especially when it is untreated, increases childhood asthma risk. Early detection and appropriate treatment of hypothyroidism in pregnant women may be an area for possible prevention of childhood asthma.

AB - Background: There is increasing interest in the possible link between maternal hypothyroidism in the perinatal period and childhood asthma risk. We explored this in this study while accounting for the timing of hypothyroidism diagnosis. Further, we evaluated whether the risk was moderated by thyroid hormone treatment during pregnancy. Methods: We conducted a population-based cohort study using Danish national registers. All live-born singletons in Denmark from 1998 to 2007 were identified. Maternal hypothyroidism and asthma in the children were defined by data from the Patient Register and Prescription Registry. We estimated incidence rate ratios (IRRs) of asthma among children born to hypothyroid mothers versus children born to mothers with no recorded thyroid dysfunction using Poisson regression models. Results: Of 595 669 children, 3524 children were born to mothers with hypothyroidism diagnosed before delivery and 4664 diagnosed after delivery. Overall, 48 990 children received treatment for asthma. The IRRs of asthma was 1.16 (95% confidence interval (CI): 1.03-1.30) and 1.12 (95% CI: 1.02-1.24) for children born to mothers with hypothyroidism diagnosed before and after delivery, compared to children born to mothers with no thyroid dysfunction. The highest risk was observed among children born to mothers with hypothyroidism diagnosed before delivery who did not receive thyroid hormone treatment during pregnancy (IRR=1.37, 95% CI: 1.04-1.80). Conclusion: Our findings suggest that maternal hypothyroidism, especially when it is untreated, increases childhood asthma risk. Early detection and appropriate treatment of hypothyroidism in pregnant women may be an area for possible prevention of childhood asthma.

KW - Journal Article

KW - cohort study

KW - childhood

KW - hypothyroidism

KW - perinatal

KW - asthma

KW - MANAGEMENT

KW - THYROID-FUNCTION

KW - RISK

KW - MATURATION

KW - CHILDREN

KW - WOMEN

KW - SUBCLINICAL HYPOTHYROIDISM

KW - DYSFUNCTION

KW - PREGNANCY OUTCOMES

KW - DANISH NATIONWIDE COHORT

KW - Humans

KW - Child, Preschool

KW - Hypothyroidism/epidemiology

KW - Young Adult

KW - Pregnancy Complications/epidemiology

KW - Adult

KW - Female

KW - Child

KW - Prenatal Exposure Delayed Effects/epidemiology

KW - Risk Factors

KW - Pregnancy

KW - Asthma/epidemiology

KW - Cohort Studies

U2 - 10.1111/all.13365

DO - 10.1111/all.13365

M3 - Journal article

C2 - 29159833

VL - 73

SP - 932

EP - 939

JO - Allergy: European Journal of Allergy and Clinical Immunology, Supplement

JF - Allergy: European Journal of Allergy and Clinical Immunology, Supplement

SN - 0108-1675

IS - 4

ER -

Department of Economics and Business Economics