Department of Economics and Business Economics

Maternal Exposure to Occupational Asthmagens During Pregnancy and Autism Spectrum Disorder in the Study to Explore Early Development

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DOI

  • Alison B Singer, Department of Epidemiology and Wendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, MD, 21205, USA. alison_singer@unc.edu.
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  • Gayle C Windham, Division of Environmental and Occupational Disease, California Department of Public Health, Richmond, CA, USA.
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  • Lisa A Croen, Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA
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  • Julie L Daniels, Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA.
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  • Brian K Lee, Department of Epidemiology and Biostatistics and the A.J. Drexel Autism Institute, Drexel University Dornsife School of Public Health, Philadelphia, PA, USA.
  • ,
  • Yinge Qian, Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA
  • ,
  • Diana Schendel
  • M Daniele Fallin, Department of Epidemiology and Wendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, MD, 21205, USA.
  • ,
  • Igor Burstyn, Department of Epidemiology and Biostatistics and the A.J. Drexel Autism Institute, Drexel University Dornsife School of Public Health, Philadelphia, PA, USA.

Maternal immune activity has been linked to children with autism spectrum disorder (ASD). We examined maternal occupational exposure to asthma-causing agents during pregnancy in relation to ASD risk. Our sample included 463 ASD cases and 710 general population controls from the Study to Explore Early Development whose mothers reported at least one job during pregnancy. Asthmagen exposure was estimated from a published job-exposure matrix. The adjusted odds ratio for ASD comparing asthmagen-exposed to unexposed was 1.39 (95 % CI 0.96-2.02). Maternal workplace asthmagen exposure was not associated with ASD risk in this study, but this result does not exclude some involvement of maternal exposure to asthma-causing agents in ASD.

Original languageEnglish
JournalJournal of Autism and Developmental Disorders
Volume46
Issue11
Pages (from-to)3458-3468
Number of pages11
ISSN0162-3257
DOIs
Publication statusPublished - Nov 2016

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