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Mannose-binding lectin and risk of infections in type 2 diabetes: A Danish cohort study

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Mannose-binding lectin and risk of infections in type 2 diabetes : A Danish cohort study. / Gedebjerg, Anne; Thomsen, Reimar Wernich; Kjaergaard, Alisa Devedzic et al.

In: Journal of Diabetes and its Complications, Vol. 35, No. 5, 107873, 05.2021.

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Gedebjerg A, Thomsen RW, Kjaergaard AD, Steffensen R, Nielsen JS, Rungby J, Friborg SG, Brandslund I, Thiel S, Beck-Nielsen H, et al. 2021. Mannose-binding lectin and risk of infections in type 2 diabetes: A Danish cohort study. Journal of Diabetes and its Complications. 35(5):Article 107873. https://doi.org/10.1016/j.jdiacomp.2021.107873

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@article{31e3959d77ae4caf95c9c906a13be078,
title = "Mannose-binding lectin and risk of infections in type 2 diabetes: A Danish cohort study",
abstract = "AIMS: In individuals at increased risk of infections, e.g., patients with type 2 diabetes, low MBL may have detrimental effects. We used the Mendelian randomization principle to examine whether genetically low MBL is a risk factor for developing infections in patients with type 2 diabetes.METHODS: Serum MBL (n = 7305) and MBL genotype (n = 3043) were determined in a nationwide cohort of patients with new type 2 diabetes and up to 8 years follow-up for hospital-treated infections and community-based antimicrobial prescriptions. The associations were examined in spline and Cox regression analyses.RESULTS: 1140 patients (16%) were hospitalized with an infection and 5077 patients (70%) redeemed an antimicrobial prescription. For low (≤100 μg/L) versus intermediate (101-1000 μg/L) serum MBL concentration, the adjusted hazard ratios (aHRs) were 1.13(95% confidence interval, 0.96-1.33) for any hospital-treated infections and 1.19(1.01-1.41) for bacterial infections. Low MBL expression genotype was not associated with risk of any hospital-treated infections except for diarrheal diseases (aHR 2.23[1.04-4.80]). Low MBL expression genotype, but not low serum MBL, was associated with increased risk for antimicrobial prescriptions (aHR 1.18[1.04-2.34] and antibacterial prescriptions 1.20[1.05-1.36]).CONCLUSIONS: Low MBL is a weak causal risk factor for developing infections in patients with type 2 diabetes.",
author = "Anne Gedebjerg and Thomsen, {Reimar Wernich} and Kjaergaard, {Alisa Devedzic} and Rudi Steffensen and Nielsen, {Jens Steen} and J{\o}rgen Rungby and Friborg, {S{\o}ren Gunnar} and Ivan Brandslund and Steffen Thiel and Henning Beck-Nielsen and S{\o}rensen, {Henrik Toft} and Hansen, {Troels Krarup} and Mette Bjerre",
note = "Copyright {\textcopyright} 2021 Elsevier Inc. All rights reserved.",
year = "2021",
month = may,
doi = "10.1016/j.jdiacomp.2021.107873",
language = "English",
volume = "35",
journal = "Journal of Diabetes and its Complications",
issn = "1056-8727",
publisher = "Elsevier Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - Mannose-binding lectin and risk of infections in type 2 diabetes

T2 - A Danish cohort study

AU - Gedebjerg, Anne

AU - Thomsen, Reimar Wernich

AU - Kjaergaard, Alisa Devedzic

AU - Steffensen, Rudi

AU - Nielsen, Jens Steen

AU - Rungby, Jørgen

AU - Friborg, Søren Gunnar

AU - Brandslund, Ivan

AU - Thiel, Steffen

AU - Beck-Nielsen, Henning

AU - Sørensen, Henrik Toft

AU - Hansen, Troels Krarup

AU - Bjerre, Mette

N1 - Copyright © 2021 Elsevier Inc. All rights reserved.

PY - 2021/5

Y1 - 2021/5

N2 - AIMS: In individuals at increased risk of infections, e.g., patients with type 2 diabetes, low MBL may have detrimental effects. We used the Mendelian randomization principle to examine whether genetically low MBL is a risk factor for developing infections in patients with type 2 diabetes.METHODS: Serum MBL (n = 7305) and MBL genotype (n = 3043) were determined in a nationwide cohort of patients with new type 2 diabetes and up to 8 years follow-up for hospital-treated infections and community-based antimicrobial prescriptions. The associations were examined in spline and Cox regression analyses.RESULTS: 1140 patients (16%) were hospitalized with an infection and 5077 patients (70%) redeemed an antimicrobial prescription. For low (≤100 μg/L) versus intermediate (101-1000 μg/L) serum MBL concentration, the adjusted hazard ratios (aHRs) were 1.13(95% confidence interval, 0.96-1.33) for any hospital-treated infections and 1.19(1.01-1.41) for bacterial infections. Low MBL expression genotype was not associated with risk of any hospital-treated infections except for diarrheal diseases (aHR 2.23[1.04-4.80]). Low MBL expression genotype, but not low serum MBL, was associated with increased risk for antimicrobial prescriptions (aHR 1.18[1.04-2.34] and antibacterial prescriptions 1.20[1.05-1.36]).CONCLUSIONS: Low MBL is a weak causal risk factor for developing infections in patients with type 2 diabetes.

AB - AIMS: In individuals at increased risk of infections, e.g., patients with type 2 diabetes, low MBL may have detrimental effects. We used the Mendelian randomization principle to examine whether genetically low MBL is a risk factor for developing infections in patients with type 2 diabetes.METHODS: Serum MBL (n = 7305) and MBL genotype (n = 3043) were determined in a nationwide cohort of patients with new type 2 diabetes and up to 8 years follow-up for hospital-treated infections and community-based antimicrobial prescriptions. The associations were examined in spline and Cox regression analyses.RESULTS: 1140 patients (16%) were hospitalized with an infection and 5077 patients (70%) redeemed an antimicrobial prescription. For low (≤100 μg/L) versus intermediate (101-1000 μg/L) serum MBL concentration, the adjusted hazard ratios (aHRs) were 1.13(95% confidence interval, 0.96-1.33) for any hospital-treated infections and 1.19(1.01-1.41) for bacterial infections. Low MBL expression genotype was not associated with risk of any hospital-treated infections except for diarrheal diseases (aHR 2.23[1.04-4.80]). Low MBL expression genotype, but not low serum MBL, was associated with increased risk for antimicrobial prescriptions (aHR 1.18[1.04-2.34] and antibacterial prescriptions 1.20[1.05-1.36]).CONCLUSIONS: Low MBL is a weak causal risk factor for developing infections in patients with type 2 diabetes.

U2 - 10.1016/j.jdiacomp.2021.107873

DO - 10.1016/j.jdiacomp.2021.107873

M3 - Journal article

C2 - 33627253

VL - 35

JO - Journal of Diabetes and its Complications

JF - Journal of Diabetes and its Complications

SN - 1056-8727

IS - 5

M1 - 107873

ER -