Mannan-binding lectin in cerebrospinal fluid: a leptomeningeal protein

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  • Hansotto Reiber, Neurochemistry Laboratory, University Göttingen, Göttingen, Germany. ho@horeiber.de.
  • ,
  • Barbara Padilla-Docal
  • ,
  • Jens Christian Jensenius
  • Alberto Juan Dorta-Contreras
Mannan-binding lectin (MBL), a protein of the innate immune response is attracting increasing clinical interest, in particularly in relation to its deficiency. Due to its involvement in brain diseases, identifying the source of MBL in CSF is important. Analysis of cerebrospinal fluid (CSF) can provide data that discriminates between blood-, brain-, and leptomeninges-derived proteins. To detect the source of MBL in CSF we need to consider three variables: the molecular size-dependent concentration gradient between CSF and blood, the variation in transfer between blood and CSF, and the CSF MBL concentration correlation with the albumin CSF/serum quotient (QAlb), i.e., with CSF flow rate.
Original languageEnglish
JournalFluids and Barriers of the CNS
Volume9
Issue1
Pages (from-to)17
ISSN2045-8118
DOIs
Publication statusPublished - 2012

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