Management of the vertebrae as an organ at risk in paediatric radiotherapy clinical trials: Initial QUARTET experience

Andrada Turcas*, Sarah M. Kelly, Valérie Bernier-Chastagner, Stephanie Bolle, Alison Cameron, Coreen Corning, Enrico Clementel, Karin Dieckmann, Raquel Davila Fajardo, Mark N. Gaze, Anne Laprie, Henriette Magelssen, Silvia Meroni, Emanuele Pignoli, Akmal Safwat, Giovanni Scarzello, James Talbot, Beate Timmermann, Tom Boterberg, Henry C. Mandeville

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

Irradiation of the vertebrae in prepubertal patients, if non-homogenous, can result in future growth deformities including kyphoscoliosis. Vertebral delineation and dosimetry were assessed for 101 paediatric cases reviewed within QUARTET-affiliated trials. Despite the availability of published consensus guidelines, a high variability in vertebral delineation was observed, with impact on dosimetry.

Original languageEnglish
Article number109810
JournalRadiotherapy and Oncology
Volume187
ISSN0167-8140
DOIs
Publication statusPublished - Oct 2023

Keywords

  • Clinical trial
  • Pediatrics
  • Quality assurance
  • Radiotherapy
  • Vertebrae

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