Maid (GCIP) is involved in cell cycle control of hepatocytes.

TY - JOUR

T1 - Maid (GCIP) is involved in cell cycle control of hepatocytes.

AU - Sonnenberg-Riethmacher, Eva

AU - Wüstefeld, Torsten

AU - Miehe, Michaela

AU - Trautwein, Christian

AU - Riethmacher, Dieter

PY - 2007/2

Y1 - 2007/2

N2 - The function of Maid (GCIP), a cyclinD-binding helix-loop-helix protein, was analyzed by targeted disruption in mice. We show that Maid function is not required for normal embryonic development. However, older Maid-deficient mice-in contrast to wild-type controls--develop hepatocellular carcinomas.Therefore, we studied the role of Maid during cell cycle progression after partial hepatectomy (PH). Lack of Maid expression after PH was associated with a delay in G1/S-phase progression as evidenced by delayed cyclinA expression and DNA replication in Maid-deficient mice. However, at later time points liver mass was restored normally.These results indicate that Maid is involved in G1/S-phase progression of hepatocytes, which in older animals is associated with the development of liver tumors.

AB - The function of Maid (GCIP), a cyclinD-binding helix-loop-helix protein, was analyzed by targeted disruption in mice. We show that Maid function is not required for normal embryonic development. However, older Maid-deficient mice-in contrast to wild-type controls--develop hepatocellular carcinomas.Therefore, we studied the role of Maid during cell cycle progression after partial hepatectomy (PH). Lack of Maid expression after PH was associated with a delay in G1/S-phase progression as evidenced by delayed cyclinA expression and DNA replication in Maid-deficient mice. However, at later time points liver mass was restored normally.These results indicate that Maid is involved in G1/S-phase progression of hepatocytes, which in older animals is associated with the development of liver tumors.

M3 - Journal article

SN - 0270-9139

VL - 45

SP - 404

JO - Hepatology

JF - Hepatology

IS - 2

ER -