Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses

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DOI

  • Franziska Schandock, Institute of Molecular Virology, Ulm University Medical Center, Meyerhofstrasse 1, 89081, Ulm, Germany.
  • ,
  • Camilla Frich Riber
  • ,
  • Annika Röcker, Institute of Molecular Virology, Ulm University Medical Center, Meyerhofstrasse 1, 89081, Ulm, Germany.
  • ,
  • Janis A Müller, Institute of Molecular Virology, Ulm University Medical Center, Meyerhofstrasse 1, 89081, Ulm, Germany.
  • ,
  • Mirja Harms, Institute of Molecular Virology, Ulm University Medical Center, Meyerhofstrasse 1, 89081, Ulm, Germany.
  • ,
  • Paulina Gajda
  • ,
  • Kaja Zuwala
  • Anna H F Andersen
  • Kaja Borup Løvschall
  • ,
  • Martin Tolstrup
  • Florian Kreppel, Institute of Molecular Virology, Ulm University Medical Center, Meyerhofstrasse 1, 89081, Ulm, Germany.
  • ,
  • Jan Münch, Institute of Molecular Virology, Ulm University Medical Center, Meyerhofstrasse 1, 89081, Ulm, Germany.
  • ,
  • Alexander N Zelikin

Viral pathogens continue to constitute a heavy burden on healthcare and socioeconomic systems. Efforts to create antiviral drugs repeatedly lag behind the advent of pathogens and growing understanding is that broad-spectrum antiviral agents will make strongest impact in future antiviral efforts. This work performs selection of synthetic polymers as novel broadly active agents and demonstrates activity of these polymers against Zika, Ebola, Lassa, Lyssa, Rabies, Marburg, Ebola, influenza, herpes simplex, and human immunodeficiency viruses. Results presented herein offer structure-activity relationships for these pathogens in terms of their susceptibility to inhibition by polymers, and for polymers in terms of their anionic charge and hydrophobicity that make up broad-spectrum antiviral agents. The identified leads cannot be predicted based on prior data on polymer-based antivirals and represent promising candidates for further development as preventive microbicides.

Original languageEnglish
JournalAdvanced Healthcare Materials
ISSN2192-2640
DOIs
Publication statusPublished - Dec 2017

    Research areas

  • Journal Article

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ID: 118008567