Low prevalence of DNA viruses in the human endometrium and endometriosis

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  • Anna Lindeløv Vestergaard, Denmark
  • Ulla Breth Knudsen
  • Torben Munk, Gyncological-Obstetric Department, Odense University Hospital, 5000, Odense C, Denmark, Odense Universitet, Denmark
  • Hanne Rosbach, Gyncological-Obstetric Department, Odense University Hospital, 5000, Odense C, Denmark, Odense Universitet, Denmark
  • Seweryn Bialasiewicz, University of Queensland, Australia
  • Theo Sloots, University of Queensland, Australia
  • Pia Møller Martensen
  • Annika Antonsson, University of Queenland, Australia
The chronic female disease endometriosis causes debilitating pain and lowered fertility. The aetiology is unknown, but indications of an infectious agent are present. This study investigates the possible involvement of a pathogenic virus in endometriosis patients and controls. DNA was purified from biopsies and subjected to highly sensitive PCR tests detecting human papillomavirus (HPV) types, the herpes family viruses HSV-1 and -2, CMV, and EBV, and the polyomaviruses SV40, JCV, BKV, KIV, WUV, and MCV. The prevalence of pathogenic DNA viruses in the human endometrium was generally low (0-10%). The virus prevalence was found to vary slightly when comparing the endometrium of healthy women and women with endometriosis. However, these were not significant differences, and no viruses were identified in endometriotic lesions. These results do not point towards any evidence that endometriosis is caused by these viruses.
Original languageEnglish
JournalArchives of Virology
Volume155
Pages (from-to)695-703
Number of pages9
ISSN0304-8608
DOIs
Publication statusPublished - 2010

    Research areas

  • Endometriosis, Endometrium, Interferon, Virus, HPV, Herpes, Polyomavirus, Papillomavirus

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