Low physical activity is associated with impaired endothelial function in patients with type 2 diabetes and controls after 5 years of follow-up

Jonathan Mathias Baier; Kristian Løkke Funck; Liv Vernstrøm; Esben Laugesen; Per Løgstrup Poulsen

doi:10.1186/s12902-021-00857-9

Low physical activity is associated with impaired endothelial function in patients with type 2 diabetes and controls after 5 years of follow-up

Jonathan Mathias Baier, Kristian Løkke Funck, Liv Vernstrøm, Esben Laugesen, Per Løgstrup Poulsen

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

4 Citations (Scopus)

Abstract

BACKGROUND: The long-term association between physical activity and endothelial function has not previously been investigated in patients with type 2 diabetes. Therefore, we aimed to evaluate the relationship between physical activity and endothelial function, assessed by peripheral arterial tonometry, in patients with type 2 diabetes and non-diabetic controls after 5 years of follow-up.

METHODS: We included 51 patients with newly diagnosed type 2 diabetes and 53 sex- and age matched controls. Participants underwent baseline clinical characterization including objective measurement of physical activity level using accelerometery. After 5 years of follow-up, participants were re-examined, and endothelial function was assessed as natural logarithm of reactive hyperemia index (lnRHI).

RESULTS: Physical activity at baseline was associated with lnRHI after 5 years of follow-up in both patients with type 2 diabetes and controls. An increase of 1 standard deviation (SD) in daytime physical activity corresponded to a 6.7 % increase in RHI (95 % confidence interval: 1.1;12.5 %, p = 0.02). We found no difference in lnRHI between patients with diabetes and controls (0.67 ± 0.29 vs. 0.73 ± 0.31, p = 0.28).

CONCLUSIONS: Daytime physical activity is associated with endothelial function after 5 years of follow-up in patients with type 2 diabetes and controls.

Original language	English
Article number	189
Journal	BMC Endocrine Disorders
Volume	21
Issue	1
Number of pages	7
ISSN	1472-6823
DOIs	https://doi.org/10.1186/s12902-021-00857-9
Publication status	Published - Dec 2021

Keywords

Accelerometery
EndoPAT
Endothelial dysfunction
Endothelial function
Peripheral arterial tonometry
Physical activity
Reactive hyperemia index
Type 2 diabetes

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10.1186/s12902-021-00857-9

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449475/pdf/12902_2021_Article_857.pdf

Cite this

@article{d090120939e94e7298db83a631cf3d3f,

title = "Low physical activity is associated with impaired endothelial function in patients with type 2 diabetes and controls after 5 years of follow-up",

abstract = "BACKGROUND: The long-term association between physical activity and endothelial function has not previously been investigated in patients with type 2 diabetes. Therefore, we aimed to evaluate the relationship between physical activity and endothelial function, assessed by peripheral arterial tonometry, in patients with type 2 diabetes and non-diabetic controls after 5 years of follow-up.METHODS: We included 51 patients with newly diagnosed type 2 diabetes and 53 sex- and age matched controls. Participants underwent baseline clinical characterization including objective measurement of physical activity level using accelerometery. After 5 years of follow-up, participants were re-examined, and endothelial function was assessed as natural logarithm of reactive hyperemia index (lnRHI).RESULTS: Physical activity at baseline was associated with lnRHI after 5 years of follow-up in both patients with type 2 diabetes and controls. An increase of 1 standard deviation (SD) in daytime physical activity corresponded to a 6.7 % increase in RHI (95 % confidence interval: 1.1;12.5 %, p = 0.02). We found no difference in lnRHI between patients with diabetes and controls (0.67 ± 0.29 vs. 0.73 ± 0.31, p = 0.28).CONCLUSIONS: Daytime physical activity is associated with endothelial function after 5 years of follow-up in patients with type 2 diabetes and controls.",

keywords = "Accelerometery, EndoPAT, Endothelial dysfunction, Endothelial function, Peripheral arterial tonometry, Physical activity, Reactive hyperemia index, Type 2 diabetes",

author = "Baier, {Jonathan Mathias} and Funck, {Kristian L{\o}kke} and Liv Vernstr{\o}m and Esben Laugesen and Poulsen, {Per L{\o}gstrup}",

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year = "2021",

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doi = "10.1186/s12902-021-00857-9",

language = "English",

volume = "21",

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Low physical activity is associated with impaired endothelial function in patients with type 2 diabetes and controls after 5 years of follow-up. / Baier, Jonathan Mathias ; Funck, Kristian Løkke ; Vernstrøm, Liv et al.
In: BMC Endocrine Disorders, Vol. 21, No. 1, 189, 12.2021.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Low physical activity is associated with impaired endothelial function in patients with type 2 diabetes and controls after 5 years of follow-up

AU - Baier, Jonathan Mathias

AU - Funck, Kristian Løkke

AU - Vernstrøm, Liv

AU - Laugesen, Esben

AU - Poulsen, Per Løgstrup

PY - 2021/12

Y1 - 2021/12

N2 - BACKGROUND: The long-term association between physical activity and endothelial function has not previously been investigated in patients with type 2 diabetes. Therefore, we aimed to evaluate the relationship between physical activity and endothelial function, assessed by peripheral arterial tonometry, in patients with type 2 diabetes and non-diabetic controls after 5 years of follow-up.METHODS: We included 51 patients with newly diagnosed type 2 diabetes and 53 sex- and age matched controls. Participants underwent baseline clinical characterization including objective measurement of physical activity level using accelerometery. After 5 years of follow-up, participants were re-examined, and endothelial function was assessed as natural logarithm of reactive hyperemia index (lnRHI).RESULTS: Physical activity at baseline was associated with lnRHI after 5 years of follow-up in both patients with type 2 diabetes and controls. An increase of 1 standard deviation (SD) in daytime physical activity corresponded to a 6.7 % increase in RHI (95 % confidence interval: 1.1;12.5 %, p = 0.02). We found no difference in lnRHI between patients with diabetes and controls (0.67 ± 0.29 vs. 0.73 ± 0.31, p = 0.28).CONCLUSIONS: Daytime physical activity is associated with endothelial function after 5 years of follow-up in patients with type 2 diabetes and controls.

AB - BACKGROUND: The long-term association between physical activity and endothelial function has not previously been investigated in patients with type 2 diabetes. Therefore, we aimed to evaluate the relationship between physical activity and endothelial function, assessed by peripheral arterial tonometry, in patients with type 2 diabetes and non-diabetic controls after 5 years of follow-up.METHODS: We included 51 patients with newly diagnosed type 2 diabetes and 53 sex- and age matched controls. Participants underwent baseline clinical characterization including objective measurement of physical activity level using accelerometery. After 5 years of follow-up, participants were re-examined, and endothelial function was assessed as natural logarithm of reactive hyperemia index (lnRHI).RESULTS: Physical activity at baseline was associated with lnRHI after 5 years of follow-up in both patients with type 2 diabetes and controls. An increase of 1 standard deviation (SD) in daytime physical activity corresponded to a 6.7 % increase in RHI (95 % confidence interval: 1.1;12.5 %, p = 0.02). We found no difference in lnRHI between patients with diabetes and controls (0.67 ± 0.29 vs. 0.73 ± 0.31, p = 0.28).CONCLUSIONS: Daytime physical activity is associated with endothelial function after 5 years of follow-up in patients with type 2 diabetes and controls.

KW - Accelerometery

KW - EndoPAT

KW - Endothelial dysfunction

KW - Endothelial function

KW - Peripheral arterial tonometry

KW - Physical activity

KW - Reactive hyperemia index

KW - Type 2 diabetes

U2 - 10.1186/s12902-021-00857-9

DO - 10.1186/s12902-021-00857-9

M3 - Journal article

C2 - 34535107

SN - 1472-6823

VL - 21

JO - BMC Endocrine Disorders

JF - BMC Endocrine Disorders

IS - 1

M1 - 189

ER -

Low physical activity is associated with impaired endothelial function in patients with type 2 diabetes and controls after 5 years of follow-up

Abstract

Keywords

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